Genetic variant
rs340005
rs340005 is a single-letter difference in human DNA, on chromosome 15. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs340005 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
LOCI AFFECTING GAMMA-GLUTAMYL TRANSFERASE IN ADULTS AND ADOLESCENTS SHOW AGE X SNP INTERACTION AND CARDIOMETABOLIC DISEASE ASSOCIATIONS
From SNPedia
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs340005, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs340005
- Position
- chr15:60585831
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| C-reactive protein levels | G | β 0.032 | 7E-51 | PubMed |
| C-reactive protein levels (MTAG) | A | β 0.03 | 1E-47 | PubMed |
| C-reactive protein levels (UKB data field 30710) | A | β 0.028 | 8E-45 | PubMed |
| C-reactive protein | A | β 0.029 | 2E-34 | PubMed |
| Total bilirubin levels | A | β 0.024 | 5E-27 | PubMed |
| Gamma glutamyl transferase levels | G | β 0.053 | 4E-24 | PubMed |
| chloride (minimum, inv-norm transformed) | G | β 0.028 | 1E-23 | PubMed |
| Gamma glutamyl transferase levels | A | β 0.053 | 1E-23 | PubMed |
| hematocrit (mean, inv-norm transformed) | G | β 0.027 | 2E-21 | PubMed |
| Gamma glutamyl transferase levels | — | β 0.055 | 2E-20 | PubMed |
| chloride (mean, inv-norm transformed) | G | β 0.027 | 5E-20 | PubMed |
| chloride (minimum, inv-norm transformed) | G | β 0.025 | 9E-19 | PubMed |
| Serum total protein levels | A | β 0.02 | 3E-17 | PubMed |
| red blood cell count (RBC, mean, inv-norm transformed) | G | β 0.024 | 4E-17 | PubMed |
| C-reactive protein levels | A | β 0.03 | 1E-15 | PubMed |
| hematocrit (minimum, inv-norm transformed) | G | β 0.022 | 1E-15 | PubMed |
| hemoglobin (mean, inv-norm transformed) | G | β 0.022 | 2E-15 | PubMed |
| Phenylalanine levels | A | β 0.02 | 9E-15 | PubMed |
| C-reactive protein levels | A | β 0.03 | 4E-14 | PubMed |
| Sodium (mean, inv-norm transformed) | G | β 0.02 | 5E-13 | PubMed |
Sources
- dbSNP: rs340005 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies