Genetic variant
rs339969
rs339969 is a single-letter difference in human DNA, on chromosome 15. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs339969 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
We hold only the basic reference record for this variant: its ID and position. Many catalogued variants have never been linked to anything.
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs339969, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs339969
- Position
- chr15:60591082
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Gamma glutamyl transferase levels | A | β 0.07 | 3E-276 | PubMed |
| Gamma glutamyl transferase levels | C | β 0.016 | 1E-215 | PubMed |
| Liver enzyme levels (gamma-glutamyl transferase) | C | β 0.016 | 2E-197 | PubMed |
| Gamma glutamyltransferase levels (UKB data field 30730) | A | β 0.054 | 8E-193 | PubMed |
| Gamma glutamyl transpeptidase | A | β 0.059 | 2E-167 | PubMed |
| SERPINA12 protein levels | A | β 0.082 | 1E-69 | PubMed |
| C-reactive protein levels | A | β 0.034 | 1E-56 | PubMed |
| Total bilirubin levels | A | β 0.031 | 9E-48 | PubMed |
| XPNPEP2 protein levels | A | β 0.077 | 7E-43 | PubMed |
| Albumin levels | A | β 0.026 | 1E-34 | PubMed |
| CDHR2 protein levels | A | β 0.055 | 1E-33 | PubMed |
| Free Cholesterol to Total Lipids in Large HDL percentage | A | β 0.02 | 2E-33 | PubMed |
| Total bilirubin levels (UKB data field 30840) | A | β 0.018 | 1E-32 | PubMed |
| CHI3L1 protein levels | A | β 0.06 | 7E-32 | PubMed |
| Alanine transaminase (ALT, mean, inv-norm transformed) | C | β 0.031 | 3E-31 | PubMed |
| Alanine transaminase (ALT, maximum, inv-norm transformed) | C | β 0.03 | 3E-30 | PubMed |
| TREH protein levels | A | β 0.02 | 4E-30 | PubMed |
| Phospholipids to Total Lipids in Very Large HDL percentage | A | β 0.02 | 2E-29 | PubMed |
| Alanine aminotransferase levels | A | β 0.021 | 3E-28 | PubMed |
| chloride (mean, inv-norm transformed) | C | β 0.031 | 9E-27 | PubMed |
Sources
- dbSNP: rs339969 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies