Genetic variant
rs33912345
rs33912345 is a single-letter difference in human DNA, on chromosome 14. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs33912345 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
We hold only the basic reference record for this variant: its ID and position. Many catalogued variants have never been linked to anything.
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs33912345, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs33912345
- Position
- chr14:60509819
Genome-wide association studies (19)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Height | — | — | 5E-125 | PubMed |
| Standing height (UKB data field 50) | A | β 0.024 | 2E-117 | PubMed |
| Primary open angle glaucoma (multi-trait analysis) | A | OR 0.16 | 6E-85 | PubMed |
| Glaucoma | C | β 0.091 | 1E-56 | PubMed |
| Glaucoma (primary open-angle) | — | OR 0.14 | 3E-55 | PubMed |
| Glaucoma (primary open-angle) | A | OR 0.11 | 3E-54 | PubMed |
| Basal metabolic rate (UKB data field 23105) | A | β 0.018 | 8E-52 | PubMed |
| Whole body fat free mass (UKB data field 23101) | A | β 0.019 | 9E-43 | PubMed |
| Glaucoma (primary open-angle) | A | OR 0.84 | 4E-39 | PubMed |
| Primary open angle glaucoma (PheCode 365.11) | C | OR 0.12 | 5E-34 | PubMed |
| IGF 1 (UKB data field 30770) | A | β 0.021 | 5E-29 | PubMed |
| Glaucoma (primary open-angle) | A | OR 0.81 | 3E-18 | PubMed |
| Medication use (antiglaucoma preparations and miotics) | A | OR 0.13 | 5E-18 | PubMed |
| Takes medication for Glaucoma? | C | β 0.095 | 2E-14 | PubMed |
| Takes medication for Glaucoma? | C | β 0.088 | 2E-13 | PubMed |
| Medication use (antiglaucoma preparations and miotics) | C | OR 0.15 | 1E-12 | PubMed |
| Refractive error | C | β 0.041 | 5E-11 | PubMed |
| Glaucoma (high intraocular pressure) | A | — | 1E-9 | PubMed |
| Appendicular lean mass | A | β 0.04 | 8E-9 | PubMed |
Sources
- dbSNP: rs33912345 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies