Genetic variant
rs331
rs331 is a single-letter difference in human DNA, on chromosome 8. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs331 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
We hold only the basic reference record for this variant: its ID and position. Many catalogued variants have never been linked to anything.
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs331, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs331
- Position
- chr8:19962894
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Apolipoprotein A1 levels | G | β 0.088 | 5E-340 | PubMed |
| Metabolic syndrome | G | OR 0.16 | 2E-33 | PubMed |
| Coronary atherosclerosis (PheCode 411.4) | G | β 0.057 | 8E-25 | PubMed |
| Linoleic acid levels | A | — | 5E-23 | PubMed |
| Fasting total lipids in small VLDL | A | OR 0.21 | 1E-20 | PubMed |
| Fasting small VLDL particle concentration | A | OR 0.21 | 1E-20 | PubMed |
| 3-Hydroxybutyrate levels | A | β 0.02 | 2E-20 | PubMed |
| Fasting free cholesterol in small VLDL | A | OR 0.21 | 5E-20 | PubMed |
| Fasting free cholesterol in medium VLDL | A | OR 0.21 | 1E-19 | PubMed |
| Fasting triglycerides levels in very small VLDL | A | OR 0.21 | 2E-19 | PubMed |
| Fasting phospholipid levels in small VLDL | A | OR 0.2 | 4E-19 | PubMed |
| Fasting total cholesterol in VLDL | A | OR 0.2 | 5E-19 | PubMed |
| Fasting serum total triglycerides | A | OR 0.2 | 6E-19 | PubMed |
| Abdominal aortic aneurysm | — | β 0.079 | 9E-19 | PubMed |
| Fasting glycoprotein acetyls (mainly a1-acid glycoprotein) | A | OR 0.18 | 2E-15 | PubMed |
| Lipid metabolism phenotypes | — | OR 1.21 | 1E-14 | PubMed |
| Acetoacetate levels | A | β 0.02 | 5E-14 | PubMed |
| Fasting monounsaturated fatty acids (16:1, 18:1) | A | OR 0.17 | 1E-13 | PubMed |
| CA6 protein levels | A | β 0.037 | 4E-13 | PubMed |
| PTH protein levels | A | β 0.047 | 1E-12 | PubMed |
Sources
- dbSNP: rs331 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies