Genetic variant
rs324420
rs324420 is a single-letter difference in human DNA, on chromosome 1. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs324420 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
We hold only the basic reference record for this variant: its ID and position. Many catalogued variants have never been linked to anything.
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs324420, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs324420
- Position
- chr1:46405089
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| N-palmitoylglycine levels | A | OR 0.5 | 2E-131 | PubMed |
| Metabolite peak levels (QI14127) | A | OR 0.71 | 3E-123 | PubMed |
| Metabolite levels (N-palmitoyl glycine; N-palmitoylglycine) | A | OR 0.44 | 9E-123 | PubMed |
| Metabolite levels (oleic ethanolamide; oleoyl ethanolamide) | A | OR 0.4 | 5E-104 | PubMed |
| Succinoyltaurine levels | A | OR 0.39 | 8E-101 | PubMed |
| N-palmitoylglycine levels | A | OR 0.39 | 5E-96 | PubMed |
| Oleoyl ethanolamide levels | A | OR 0.36 | 1E-83 | PubMed |
| N-palmitoylglycine levels | A | OR 0.34 | 1E-76 | PubMed |
| N-linoleoyltaurine levels | A | OR 0.5 | 1E-74 | PubMed |
| Oleoyl glycine levels | A | OR 0.55 | 6E-64 | PubMed |
| Metabolite peak levels (QI12470) | A | OR 0.49 | 5E-60 | PubMed |
| Linoleoyl ethanolamide levels | A | OR 0.32 | 8E-59 | PubMed |
| Metabolite peak levels (QI2044) | A | OR 0.47 | 2E-55 | PubMed |
| Plasma succinoyltaurine levels in chronic kidney disease | A | OR 0.27 | 6E-51 | PubMed |
| Oleoyl ethanolamide levels | A | OR 0.27 | 2E-47 | PubMed |
| Metabolite peak levels (QI2222) | A | OR 0.4 | 3E-45 | PubMed |
| Plasma N-palmitoylglycine levels in chronic kidney disease | A | OR 0.2 | 2E-41 | PubMed |
| Metabolite levels (N-oleoyltaurine) | A | OR 0.26 | 3E-40 | PubMed |
| N-oleoyltaurine levels | A | OR 0.24 | 2E-35 | PubMed |
| Metabolite peak levels (QI13988) | A | OR 0.35 | 1E-34 | PubMed |
Sources
- dbSNP: rs324420 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies