Genetic variant
rs3176336
rs3176336 is a single-letter difference in human DNA, on chromosome 6. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs3176336 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
rs3176336 shows an association with breast cancer in a British study involving ~2300 patients. The o...
From SNPedia
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs3176336, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs3176336
- Position
- chr6:36681039
Genome-wide association studies (18)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Pulse pressure | T | OR 0.16 | 3E-19 | PubMed |
| Pulse pressure | A | OR 0.16 | 3E-18 | PubMed |
| Pulse pressure | A | OR 0.16 | 4E-16 | PubMed |
| diastolic blood pressure (DBP, mean, inv-normal transformed) | A | β 0.022 | 4E-16 | PubMed |
| Aortic aneurysm (PheCode 442.1) | A | β 0.074 | 1E-14 | PubMed |
| Other aneurysm (PheCode 442) | A | β 0.071 | 1E-14 | PubMed |
| estimated glomerular filtration rate (eGFR, minimum, inv-norm transformed) | A | β 0.019 | 2E-14 | PubMed |
| creatinine (maximum, inv-norm transformed) | A | β 0.018 | 3E-13 | PubMed |
| White blood cell count | — | — | 8E-13 | PubMed |
| Other aneurysm (PheCode 442) | A | β 0.069 | 1E-12 | PubMed |
| estimated glomerular filtration rate (eGFR, mean, inv-norm transformed) | A | β 0.018 | 2E-12 | PubMed |
| Aortic aneurysm (PheCode 442.1) | A | β 0.072 | 6E-12 | PubMed |
| creatinine (mean, inv-norm transformed) | A | β 0.017 | 9E-12 | PubMed |
| Abdominal aortic aneurysm | — | β 0.056 | 7E-11 | PubMed |
| Abdominal aortic aneurysm | T | OR 1.1 | 1E-10 | PubMed |
| Breast cancer | — | OR 1.03 | 3E-10 | PubMed |
| Diastolic blood pressure | A | β 0.01 | 2E-8 | PubMed |
| Body surface area | — | β 0.002 | 5E-7 | PubMed |
Sources
- dbSNP: rs3176336 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies