Genetic variant

rs295

rs295 is a single-letter difference in human DNA, on chromosome 8. Carrying it does not, on its own, mean you have or will develop any condition.

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What is this?

Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs295 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.

We hold only the basic reference record for this variant: its ID and position. Many catalogued variants have never been linked to anything.

Why might it matter?

ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.

Do I have this variant?

If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs295, if your test read this position.

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Connect this with your blood results

A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.

Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.

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What should I do next?

  1. Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
  2. Put it in context. Add your blood results, so the variant can be read against what your body is doing.
  3. Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
  4. Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
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This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.

Technical details

dbSNP ID
rs295
Position
chr8:19958727

Genome-wide association studies (20)

TraitRisk alleleOR / betaP-valueStudy
HDL x anxiety interaction (2df test) A β 0.006 9E-38 PubMed
Postprandial triglycerides levels in small VLDL C OR 0.22 2E-19 PubMed
Postprandial small VLDL particle concentration C OR 0.22 2E-19 PubMed
Postprandial total lipids in small VLDL C OR 0.22 3E-19 PubMed
Postprandial free cholesterol in small VLDL C OR 0.22 2E-18 PubMed
Postprandial triglycerides levels in medium VLDL C OR 0.22 2E-18 PubMed
Postprandial medium VLDL particle concentration C OR 0.22 2E-18 PubMed
Postprandial total lipids in medium VLDL C OR 0.22 2E-18 PubMed
Postprandial phospholipid levels in medium VLDL C OR 0.22 3E-18 PubMed
Postprandial triglycerides in VLDL C OR 0.22 4E-18 PubMed
Postprandial total cholesterol in medium VLDL C OR 0.22 4E-18 PubMed
Postprandial free cholesterol in medium VLDL C OR 0.22 6E-18 PubMed
Postprandial phospholipid levels in small VLDL C OR 0.22 6E-18 PubMed
Postprandial cholesterol esters in medium VLDL C OR 0.21 1E-17 PubMed
Postprandial total cholesterol in VLDL C OR 0.21 2E-17 PubMed
Postprandial total cholesterol in small VLDL C OR 0.21 1E-16 PubMed
Postprandial glycoprotein acetyls (mainly a1-acid glycoprotein) C OR 0.21 2E-16 PubMed
Postprandial cholesterol esters in small VLDL C OR 0.19 1E-13 PubMed
Diacylglycerol_36:3_[M+H-H2O]1+ levels C β 0.089 5E-13 PubMed
Postprandial apolipoprotein B C OR 0.17 3E-12 PubMed

Sources