Genetic variant
rs2853677
rs2853677 is a single-letter difference in human DNA, on chromosome 5. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs2853677 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
We hold only the basic reference record for this variant: its ID and position. Many catalogued variants have never been linked to anything.
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs2853677, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs2853677
- Position
- chr5:1287079
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Telomere length (principal component 1) | G | β 0.073 | 3E-287 | PubMed |
| Clonal hematopoiesis (DNMT3A mutation) | A | OR 0.76 | 1E-115 | PubMed |
| Lung adenocarcinoma | — | OR 0.26 | 2E-110 | PubMed |
| Lung cancer | — | OR 0.19 | 1E-97 | PubMed |
| Clonal hematopoiesis (DNMT3A mutation) | A | OR 0.76 | 5E-93 | PubMed |
| Clonal hematopoiesis (mutational barcode method) | G | OR 1.27 | 2E-76 | PubMed |
| Telomere length | — | — | 8E-65 | PubMed |
| Clonal hematopoiesis (overall) | G | OR 1.28 | 3E-61 | PubMed |
| Plateletcrit | A | β 0.035 | 2E-45 | PubMed |
| Myeloproliferative neoplasms | G | OR 1.46 | 3E-44 | PubMed |
| Lung adenocarcinoma | G | OR 1.21 | 3E-44 | PubMed |
| Clonal hematopoiesis (DNMT3A mutation) | G | OR 1.28 | 6E-44 | PubMed |
| Lung adenocarcinoma | C | OR 1.41 | 3E-40 | PubMed |
| Mean corpuscular hemoglobin | A | β 0.03 | 3E-35 | PubMed |
| Plateletcrit | A | β 0.046 | 4E-35 | PubMed |
| Mean corpuscular volume | A | β 0.04 | 2E-34 | PubMed |
| Leukocyte telomere length | A | β 0.064 | 3E-31 | PubMed |
| Neutrophill percentage (UKB data field 30200) | A | β 0.023 | 2E-29 | PubMed |
| Mean reticulocyte volume | A | β 0.027 | 8E-29 | PubMed |
| Clonal hematopoiesis (small clone) | G | OR 1.24 | 5E-28 | PubMed |
Sources
- dbSNP: rs2853677 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies