Genetic variant
rs2820446
rs2820446 is a single-letter difference in human DNA, on chromosome 1. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs2820446 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
We hold only the basic reference record for this variant: its ID and position. Many catalogued variants have never been linked to anything.
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs2820446, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs2820446
- Position
- chr1:219575476
Genome-wide association studies (18)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Height | G | β 0.016 | 1E-120 | PubMed |
| Umbilical hernia | G | OR 1.26 | 8E-24 | PubMed |
| Type 2 diabetes | G | β 0.041 | 2E-22 | PubMed |
| Weight (maximum, inv-normal transformed) | C | β 0.038 | 2E-22 | PubMed |
| Weight (mean, inv-normal transformed) | C | β 0.037 | 5E-22 | PubMed |
| Weight (minimum, inv-normal transformed) | C | β 0.033 | 3E-19 | PubMed |
| Type 2 diabetes | C | β 0.059 | 3E-17 | PubMed |
| Type 2 diabetes | G | β 0.045 | 6E-17 | PubMed |
| Type 2 diabetes | C | OR 1.05 | 1E-16 | PubMed |
| Type 2 diabetes | C | OR 1.06 | 3E-16 | PubMed |
| Diabetes / "Sugar" | C | β 0.039 | 8E-13 | PubMed |
| Body mass index or osteoarthritis (pleiotropy) | C | — | 3E-12 | PubMed |
| Inguinal hernia | G | OR 1.09 | 3E-12 | PubMed |
| Body fat percentage and type 2 diabetes (pairwise) | G | — | 3E-12 | PubMed |
| Albumin levels | G | β 0.09 | 4E-12 | PubMed |
| Ventral hernia | G | OR 1.17 | 6E-10 | PubMed |
| Femoral hernia | G | OR 1.35 | 1E-8 | PubMed |
| Type 2 diabetes | C | OR 1.05 | 2E-6 | PubMed |
Sources
- dbSNP: rs2820446 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies