Genetic variant

rs2780226

rs2780226 is a single-letter difference in human DNA, on chromosome 6. Carrying it does not, on its own, mean you have or will develop any condition.

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What is this?

Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs2780226 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.

We hold only the basic reference record for this variant: its ID and position. Many catalogued variants have never been linked to anything.

Why might it matter?

ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.

Do I have this variant?

If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs2780226, if your test read this position.

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Connect this with your blood results

A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.

Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.

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What should I do next?

  1. Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
  2. Put it in context. Add your blood results, so the variant can be read against what your body is doing.
  3. Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
  4. Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
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This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.

Technical details

dbSNP ID
rs2780226
Position
chr6:34231315

Genome-wide association studies (17)

TraitRisk alleleOR / betaP-valueStudy
Height C β 0.089 1E-300 PubMed
Height C β 0.094 1E-300 PubMed
Height — β 0.09 5E-186 PubMed
Height (baseline) C β 0.063 1E-174 PubMed
Height C β 0.09 6E-141 PubMed
Anthropometric traits C β 0.067 7E-109 PubMed
Anthropometric traits (multi-trait analysis) — — 3E-69 PubMed
Height — — 3E-45 PubMed
Height C β 0.095 2E-32 PubMed
Height T β 0.076 8E-28 PubMed
Height — β 0.059 4E-20 PubMed
FVC — — 2E-14 PubMed
Waist circumference adjusted for body mass index C β 0.053 7E-14 PubMed
Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) — — 5E-12 PubMed
Birth weight T β 0.039 7E-12 PubMed
Waist circumference adjusted for BMI in active individuals C β 0.05 8E-10 PubMed
FEV1 — — 3E-8 PubMed

Sources