Genetic variant

rs267738

rs267738 is a single-letter difference in human DNA, on chromosome 1. Carrying it does not, on its own, mean you have or will develop any condition.

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What is this?

Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs267738 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.

Genome-wide association study identifies genetic risk underlying primary rhegmatogenous retinal detachment

From SNPedia

Why might it matter?

ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.

Do I have this variant?

If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs267738, if your test read this position.

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Connect this with your blood results

A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.

Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.

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What should I do next?

  1. Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
  2. Put it in context. Add your blood results, so the variant can be read against what your body is doing.
  3. Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
  4. Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
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This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.

Technical details

dbSNP ID
rs267738
Position
chr1:150968149

Genome-wide association studies (20)

TraitRisk alleleOR / betaP-valueStudy
Estimated glomerular filtration rate (creatinine) T β 0.005 3E-86 PubMed
Estimated glomerular filtration rate (creatinine) G OR 18.15 1E-73 PubMed
Creatinine levels (UKB data field 30700) G β 0.031 2E-58 PubMed
creatinine (mean, inv-norm transformed) T β 0.049 3E-58 PubMed
Estimated glomerular filtration rate (creatinine) T β 0.005 2E-57 PubMed
Creatinine levels T β 0.031 7E-51 PubMed
Estimated glomerular filtration rate T β 0.005 1E-48 PubMed
Estimated glomerular filtration rate T β 0.005 2E-48 PubMed
Apolipoprotein A1 levels T β 0.034 1E-47 PubMed
Creatinine levels G β 0.03 3E-42 PubMed
creatinine (maximum, inv-norm transformed) T β 0.039 2E-38 PubMed
creatinine (mean, inv-norm transformed) T β 0.046 1E-36 PubMed
Phospholipids to Total Lipids in Large HDL percentage G β 0.03 2E-36 PubMed
creatinine (minimum, inv-norm transformed) T β 0.045 1E-35 PubMed
estimated glomerular filtration rate (eGFR, minimum, inv-norm transformed) T β 0.036 4E-35 PubMed
high density lipoprotein cholesterol (HDLC, mean, inv-norm transformed) T β 0.041 6E-30 PubMed
high density lipoprotein cholesterol (HDLC, maximum, inv-norm transformed) T β 0.04 4E-29 PubMed
creatinine (maximum, inv-norm transformed) T β 0.038 1E-26 PubMed
High density lipoprotein cholesterol levels G β 0.022 4E-24 PubMed
Free Cholesterol to Total Lipids in Small HDL percentage G β 0.02 1E-21 PubMed

Sources