Genetic variant
rs2657880
rs2657880 is a single-letter difference in human DNA, on chromosome 12. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs2657880 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
We hold only the basic reference record for this variant: its ID and position. Many catalogued variants have never been linked to anything.
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs2657880, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs2657880
- Position
- chr12:56469986
Genome-wide association studies (19)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Tyrosine levels | G | β 0.071 | 3E-42 | PubMed |
| Fasting glutamine | C | OR 0.34 | 3E-39 | PubMed |
| Tyrosine levels | G | β 0.068 | 3E-38 | PubMed |
| Gamma-glutamylglutamine levels | C | OR 0.16 | 5E-35 | PubMed |
| Metabolite levels (glutamine) | C | OR 0.21 | 1E-31 | PubMed |
| Blood urea nitrogen (BUN, minimum, inv-norm transformed) | G | β 0.036 | 5E-30 | PubMed |
| Metabolite levels | — | — | 7E-30 | PubMed |
| Tyrosine levels (UKB data field 23469) | C | β 0.068 | 5E-29 | PubMed |
| Metabolite levels (gamma-glutamylglutamine) | C | OR 0.2 | 4E-22 | PubMed |
| Blood urea nitrogen (BUN, mean, inv-norm transformed) | G | β 0.033 | 4E-22 | PubMed |
| Blood urea nitrogen (BUN, minimum, inv-norm transformed) | G | β 0.03 | 2E-18 | PubMed |
| Albumin (maximum, inv-norm transformed) | G | β 0.028 | 3E-17 | PubMed |
| Albumin (mean, inv-norm transformed) | G | β 0.025 | 5E-14 | PubMed |
| Lysine levels | C | OR 7.46 | 9E-14 | PubMed |
| CKB protein levels | C | β 0.048 | 3E-12 | PubMed |
| Gamma-glutamylglutamine levels | C | OR 0.13 | 1E-11 | PubMed |
| Albumin (mean, inv-norm transformed) | G | β 0.023 | 4E-11 | PubMed |
| Triglycerides | G | β 0.023 | 5E-10 | PubMed |
| Triglycerides | G | β 0.024 | 9E-7 | PubMed |
Sources
- dbSNP: rs2657880 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies