Genetic variant

rs261332

rs261332 is a single-letter difference in human DNA, on chromosome 15. Carrying it does not, on its own, mean you have or will develop any condition.

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What is this?

Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs261332 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.

rs261332 increases susceptibility to Elevated HDL-Cholesterol for carriers of the A allele A allele ...

From SNPedia

Why might it matter?

ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.

Do I have this variant?

If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs261332, if your test read this position.

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Connect this with your blood results

A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.

Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.

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What should I do next?

  1. Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
  2. Put it in context. Add your blood results, so the variant can be read against what your body is doing.
  3. Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
  4. Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
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This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.

Technical details

dbSNP ID
rs261332
Position
chr15:58435126

Genome-wide association studies (20)

TraitRisk alleleOR / betaP-valueStudy
Low-density lipoprotein levels (MTAG) A β 0.064 2E-310 PubMed
Cholesteryl esters to total lipids in chylomicrons and extremely large VLDL percentage (UKB data field 23581) A β 0.095 1E-58 PubMed
Age-related disease endophenotypes — — 4E-42 PubMed
Age-related diseases, mortality and associated endophenotypes — — 2E-35 PubMed
High density lipoprotein cholesterol levels A OR 1.58 3E-25 PubMed
Total lipids in small HDL G β 0.02 2E-22 PubMed
Postprandial triglycerides levels in IDL G OR 0.26 2E-22 PubMed
High density lipoprotein cholesterol levels T OR 2.59 9E-21 PubMed
Cholesterol levels in medium VLDL A β 0.042 1E-16 PubMed
Cholesteryl ester levels in medium VLDL A β 0.041 2E-16 PubMed
Triglyceride levels (MTAG) A β 0.025 4E-16 PubMed
Hematocrit A β 0.014 1E-15 PubMed
Fasting triglycerides levels in small LDL G OR 0.19 1E-13 PubMed
Free cholesterol levels in large LDL A β 0.037 2E-13 PubMed
Phosphatidylethanolamine(38:5)_[M-H]1- levels G β 0.08 7E-13 PubMed
Phosphatidylcholine(35:4)_[M+H]1+/Phosphatidylethanolamine(38:4)_[M+H]1+/Phosphatidate(40:5)_[M+NH4]1+ levels G β 0.057 7E-13 PubMed
Phosphatidylethanolamine(40:7)_[M-H]1- levels T β 0.085 7E-13 PubMed
Phosphatidylcholine(37:6)_[M+H]1+/Phosphatidylethanolamine(40:6)_[M+H]1+/Phosphatidate(42:7)_[M+NH4]1+ levels G OR 0.19 7E-13 PubMed
Phosphatidylcholine(33:3)_[M+H]1+/Phosphatidylethanolamine(36:3)_[M+H]1+/Phosphatidate(38:4)_[M+NH4]1+ levels C OR 0.19 7E-13 PubMed
Phosphatidylcholine(33:2)_[M+H]1+/Phosphatidylethanolamine(36:2)_[M+H]1+/Phosphatidate(38:3)_[M+NH4]1+ levels A OR 0.19 7E-13 PubMed

Sources