RS2476601 Unknown gene
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What This Variant Does
"This important SNP, located in the PTPN22 gene and also known as R620W, C1858T, or 1858C>
GWAS Studies (20)
| Trait | Risk Allele | OR / Beta | P-value | Study |
|---|---|---|---|---|
| Hypothyroidism | A | OR: 0.38 | 3E-198 | PubMed |
| Hypothyroidism | A | OR: 1.41 | 3E-196 | PubMed |
| Rheumatoid arthritis (rheumatoid factor and/or anti-cyclic citrullinated peptide seropositive) | G | OR: 0.55 | 5E-174 | PubMed |
| Rheumatoid arthritis (rheumatoid factor and/or anti-cyclic citrullinated peptide seropositive) | G | OR: 0.55 | 1E-173 | PubMed |
| Hypothyroidism | — | — | 2E-173 | PubMed |
| Rheumatoid arthritis | A | OR: 1.8 | 9E-170 | PubMed |
| Medication use (thyroid preparations) | A | OR: 0.41 | 3E-169 | PubMed |
| Medication use (thyroid preparations) | G | OR: 0.41 | 3E-169 | PubMed |
| Rheumatoid arthritis | G | OR: 0.58 | 4E-169 | PubMed |
| Rheumatoid arthritis | G | OR: 0.58 | 4E-168 | PubMed |
| Hypothyroidism | G | OR: 0.42 | 2E-165 | PubMed |
| Rheumatoid arthritis (rheumatoid factor and/or anti-cyclic citrullinated peptide seropositive) | A | OR: 1.59 | 1E-160 | PubMed |
| Autoimmune thyroid disease | A | OR: 1.44 | 2E-160 | PubMed |
| Rheumatoid arthritis | A | OR: 0.6 | 2E-149 | PubMed |
| Rheumatoid arthritis | A | OR: 1.41 | 4E-144 | PubMed |
| Type 1 diabetes | A | OR: 1.72 | 5E-135 | PubMed |
| Rheumatoid arthritis (ACPA-positive) | A | OR: 1.82 | 2E-126 | PubMed |
| Autoimmune traits (pleiotropy) | A | — | 6E-119 | PubMed |
| Hypothyroidism | G | OR: 0.37 | 2E-117 | PubMed |
| Type 1 diabetes | A | OR: 2 | 2E-111 | PubMed |