Genetic variant
rs2267161
rs2267161 is a single-letter difference in human DNA, on chromosome 22. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs2267161 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
A variation in the cerebroside sulfotransferase gene is linked to exercise-modified insulin resistance and to type 2 diabetes
From SNPedia
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs2267161, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs2267161
- Position
- chr22:30557308
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Sulfatide (d18:1/16:0(OH) levels) levels | T | OR 0.3 | 1E-37 | PubMed |
| Sulfatide (d18:1/16:0) levels | T | OR 0.29 | 1E-33 | PubMed |
| Total Sulfatide levels | T | OR 0.25 | 3E-27 | PubMed |
| Sulfatide (d18:1/16:0) levels | T | OR 0.23 | 2E-21 | PubMed |
| Pallidum iron levels (quantitative susceptibility mapping) | C | β 0.064 | 3E-21 | PubMed |
| Sulfatide (d18:1/24:0(OH) levels) levels | T | OR 0.22 | 4E-21 | PubMed |
| Sulfatide (d18:1/16:0(OH) levels) levels | T | OR 0.22 | 5E-21 | PubMed |
| IDP dMRI TBSS ICVF Splenium of corpus callosum | T | β 0.09 | 2E-17 | PubMed |
| IDP dMRI TBSS ICVF Cerebral peduncle R | T | β 0.087 | 3E-16 | PubMed |
| Corpus callosum fractional anisotropy (splenium) | — | — | 4E-16 | PubMed |
| Brain morphology (MOSTest) | — | — | 5E-16 | PubMed |
| Pallidum iron levels (R2* MRI) | C | β 0.055 | 2E-15 | PubMed |
| Corpus callosum fractional anisotropy (MOSTest) | — | — | 2E-15 | PubMed |
| Sulfatide (d18:1/24:0(OH) levels) levels | T | OR 0.19 | 2E-15 | PubMed |
| IDP dMRI ProbtrackX ICVF cst l | T | β 0.084 | 2E-15 | PubMed |
| IDP dMRI ProbtrackX ICVF cst r | T | β 0.083 | 4E-15 | PubMed |
| wg lh intensity-contrast inferiorparietal | T | β 0.082 | 6E-15 | PubMed |
| Total corpus callosum volume | — | — | 6E-15 | PubMed |
| wg rh intensity-contrast lateraloccipital | T | β 0.082 | 9E-15 | PubMed |
| wg rh intensity-contrast inferiortemporal | T | β 0.081 | 2E-14 | PubMed |
Sources
- dbSNP: rs2267161 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies