Genetic variant
rs2239633
rs2239633 is a single-letter difference in human DNA, on chromosome 14. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs2239633 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
We hold only the basic reference record for this variant: its ID and position. Many catalogued variants have never been linked to anything.
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs2239633, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs2239633
- Position
- chr14:23119848
Genome-wide association studies (18)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Eosinophil count | A | β 0.035 | 2E-68 | PubMed |
| Eosinophil count | A | — | 3E-66 | PubMed |
| Eosinophil count | — | — | 4E-54 | PubMed |
| Eosinophill percentage (UKB data field 30210) | A | β 0.029 | 3E-53 | PubMed |
| Eosinophil count | A | β 0.022 | 2E-40 | PubMed |
| Eosinophill count (UKB data field 30150) | A | β 0.025 | 8E-38 | PubMed |
| Eosinophil count | A | β 0.042 | 1E-32 | PubMed |
| Eosinophil percentage of granulocytes | A | β 0.042 | 3E-31 | PubMed |
| Eosinophil count | A | β 0.029 | 1E-30 | PubMed |
| Eosinophil percentage of white cells | A | β 0.039 | 2E-29 | PubMed |
| Eosinophil percentage of white cells | A | β 0.04 | 4E-29 | PubMed |
| Eosinophil count | A | β 0.031 | 2E-17 | PubMed |
| Acute lymphoblastic leukemia (B-cell precursor) | — | — | 1E-16 | PubMed |
| Acute lymphoblastic leukemia in childhood (B cell precursor) | — | OR 1.37 | 5E-14 | PubMed |
| Monocyte count | A | β 0.051 | 4E-13 | PubMed |
| Acute lymphoblastic leukemia (childhood) | T | OR 1.27 | 7E-13 | PubMed |
| Acute lymphoblastic leukemia (childhood) | C | OR 1.35 | 4E-10 | PubMed |
| Acute lymphoblastic leukemia (childhood) | G | OR 1.34 | 3E-7 | PubMed |
Sources
- dbSNP: rs2239633 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies