RS2230288 GBA1
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What This Variant Does
"rs2230288, also known as E326K or E365K, is a variation in the GBA gene which appears to be well tol...
Associated Conditions
Parkinsonian disorder
Rigidity
Cogwheel rigidity
Tremor
6 conditions
Gaucher disease
Gaucher disease perinatal lethal
Parkinson disease
late-onset
Parkinsonian disorder
Rigidity
Cogwheel rigidity
Tremor
6 conditions
Gaucher disease
GWAS Studies (6)
| Trait | Risk Allele | OR / Beta | P-value | Study |
|---|---|---|---|---|
| Parkinson's disease | T | OR: 0.4 | 1E-18 | PubMed |
| Parkinson's disease | — | OR: 1.67 | 5E-17 | PubMed |
| Dementia with Lewy bodies | T | OR: 2.01 | 5E-16 | PubMed |
| Dementia with Lewy bodies | T | OR: 2.08 | 4E-15 | PubMed |
| Glucosylceramidase levels | T | OR: 1.14 | 1E-14 | PubMed |
| Dementia with Lewy bodies in APOE e4- carriers | — | OR: 3.41 | 7E-9 | PubMed |
Other Variants in GBA1