Genetic variant
rs2155219
rs2155219 is a single-letter difference in human DNA, on chromosome 11. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs2155219 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
23andMe reports that the T allele of rs2155219 is associated with hay fever (allergic rhinitis) and ...
From SNPedia
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs2155219, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs2155219
- Position
- chr11:76588150
Genome-wide association studies (14)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Eosinophil count | T | β 0.029 | 3E-68 | PubMed |
| Crohn's disease | A | OR 1.19 | 6E-46 | PubMed |
| Inflammatory bowel disease | T | OR 1.15 | 4E-36 | PubMed |
| Ulcerative colitis | A | OR 1.13 | 8E-21 | PubMed |
| Self-reported allergy | T | OR 0.11 | 2E-19 | PubMed |
| Allergic sensitization | T | OR 1.18 | 1E-18 | PubMed |
| Ulcerative colitis | T | OR 1.13 | 5E-16 | PubMed |
| Atopic march | T | OR 1.33 | 2E-15 | PubMed |
| Asthma | T | OR 0.11 | 3E-15 | PubMed |
| IgE grass sensitization | T | OR 1.22 | 1E-8 | PubMed |
| Allergic rhinitis | T | OR 1.17 | 4E-8 | PubMed |
| Alopecia areata | T | OR 1.21 | 4E-8 | PubMed |
| Gut microbiota (functional units) | T | OR 5.28 | 1E-7 | PubMed |
| Eosinophilic esophagitis | A | OR 1.37 | 4E-7 | PubMed |
Sources
- dbSNP: rs2155219 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies