Genetic variant
rs2075650
rs2075650 is a single-letter difference in human DNA, on chromosome 19. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs2075650 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
Located close to ApoE4, yet may independently (also) influence risk of Alzheimer's disease. A case-c...
From SNPedia
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs2075650, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs2075650
- Position
- chr19:44892362
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Alzheimer's disease | G | OR 2.53 | 1E-295 | PubMed |
| Body mass index and LDL-C (pairwise) | A | — | 2E-237 | PubMed |
| Waist-hip ratio and LDL-C (pairwise) | A | — | 2E-235 | PubMed |
| Body fat percentage and LDL-C (pairwise) | A | — | 1E-234 | PubMed |
| Alzheimer's disease or family history of Alzheimer's disease | G | — | 8E-214 | PubMed |
| Alzheimer's disease | — | OR 2.53 | 2E-157 | PubMed |
| Alzheimer's disease | G | — | 8E-130 | PubMed |
| Alzheimer's disease | G | OR 4.48 | 9E-116 | PubMed |
| Alzheimer's disease | — | OR 3.11 | 1E-39 | PubMed |
| Alzheimer's disease (late onset) | G | OR 2.94 | 5E-36 | PubMed |
| Body fat percentage and HDL-C (pairwise) | A | — | 4E-33 | PubMed |
| Waist-hip ratio and HDL-C (pairwise) | A | — | 1E-32 | PubMed |
| Body mass index and HDL-C (pairwise) | A | — | 2E-29 | PubMed |
| Waist-hip ratio and triglycerides (pairwise) | A | — | 2E-26 | PubMed |
| Body mass index | A | β 0.025 | 7E-26 | PubMed |
| Body fat percentage and triglycerides (pairwise) | A | — | 2E-25 | PubMed |
| Body mass index and triglycerides (pairwise) | A | — | 1E-23 | PubMed |
| C-reactive protein levels | — | OR 0.12 | 2E-22 | PubMed |
| Cerebrospinal fluid AB1-42 levels | — | — | 3E-22 | PubMed |
| Memory decline | — | β 0.016 | 4E-22 | PubMed |
Sources
- dbSNP: rs2075650 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies