Genetic variant
rs2049045
rs2049045 is a single-letter difference in human DNA, on chromosome 11. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs2049045 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
Alzheimer's disease risk for non ApoE4 carriers is affected by the heterozygous form of rs6265, as w...
From SNPedia
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs2049045, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs2049045
- Position
- chr11:27672694
Genome-wide association studies (19)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Body mass index | — | — | 8E-42 | PubMed |
| sodium (maximum, inv-norm transformed) | G | β 0.027 | 2E-13 | PubMed |
| Body mass index in physically active individuals | G | β 0.037 | 1E-12 | PubMed |
| C-reactive protein | C | β 0.021 | 4E-12 | PubMed |
| Smoking initiation (ever regular vs never regular) | C | β 0.02 | 1E-11 | PubMed |
| C-reactive protein levels | C | β 0.021 | 2E-11 | PubMed |
| Risk-taking tendency (4-domain principal component model) | C | β 0.022 | 3E-11 | PubMed |
| Snoring | G | OR 1.04 | 9E-11 | PubMed |
| Male puberty timing (age at voice breaking MTAG) | C | β 0.027 | 1E-10 | PubMed |
| Body mass index in physically inactive individuals | G | β 0.061 | 3E-10 | PubMed |
| Drinks per week | C | β 0.007 | 5E-10 | PubMed |
| White blood cell count | C | β 0.018 | 5E-10 | PubMed |
| Body mass index variance | — | — | 7E-10 | PubMed |
| Body mass index | G | β 0.043 | 9E-10 | PubMed |
| Snoring | G | β 0.008 | 9E-10 | PubMed |
| Problematic alcohol use (MTAG) | C | β 0.019 | 2E-9 | PubMed |
| Body mass index (joint analysis main effects and physical activity interaction) | — | — | 1E-6 | PubMed |
| Smoking cessation (MTAG) | C | β 0.009 | 3E-6 | PubMed |
| Snoring | G | β 0.01 | 4E-6 | PubMed |
Sources
- dbSNP: rs2049045 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies