Genetic variant
rs2043085
rs2043085 is a single-letter difference in human DNA, on chromosome 15. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs2043085 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
We hold only the basic reference record for this variant: its ID and position. Many catalogued variants have never been linked to anything.
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs2043085, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs2043085
- Position
- chr15:58388755
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Total cholesterol to total lipids ratio in very large HDL | T | OR 0.14 | 2E-266 | PubMed |
| Phospholipid levels in HDL | T | OR 0.13 | 1E-241 | PubMed |
| Total lipid levels in HDL | T | OR 0.12 | 4E-236 | PubMed |
| Total fatty acid levels | T | — | 1E-219 | PubMed |
| Saturated fatty acids levels | T | — | 2E-215 | PubMed |
| Total fatty acid levels | T | — | 1E-203 | PubMed |
| Phospholipids to total lipids ratio in small HDL | T | OR 0.12 | 1E-198 | PubMed |
| Phospholipids in HDL (UKB data field 23414) | T | OR 0.13 | 3E-192 | PubMed |
| Total lipids in HDL (UKB data field 23426) | T | OR 0.13 | 7E-188 | PubMed |
| Free cholesterol levels in medium HDL | T | OR 0.11 | 7E-185 | PubMed |
| Linoleic acid levels | T | — | 7E-185 | PubMed |
| Linoleic acid levels | T | — | 9E-184 | PubMed |
| Apolipoprotein A1 levels | T | OR 0.11 | 3E-176 | PubMed |
| Polyunsaturated fatty acid levels | T | — | 6E-158 | PubMed |
| Phospholipids to total lipids in small HDL percentage (UKB data field 23644) | T | OR 0.12 | 8E-156 | PubMed |
| Free cholesterol in medium HDL (UKB data field 23570) | T | OR 0.11 | 1E-147 | PubMed |
| Phospholipid levels in medium HDL | T | OR 0.1 | 2E-144 | PubMed |
| Apolipoprotein A1 levels (UKB data field 23440) | T | OR 0.11 | 5E-142 | PubMed |
| Concentration of medium HDL particles | T | β 0.097 | 8E-137 | PubMed |
| Total lipid levels in medium HDL | T | β 0.097 | 1E-135 | PubMed |
Sources
- dbSNP: rs2043085 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies