Genetic variant
rs1991866
rs1991866 is a single-letter difference in human DNA, on chromosome 8. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs1991866 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
We hold only the basic reference record for this variant: its ID and position. Many catalogued variants have never been linked to anything.
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs1991866, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs1991866
- Position
- chr8:129611859
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Mean spheric corpuscular volume | C | β 0.032 | 3E-45 | PubMed |
| Mean corpuscular volume (UKB data field 30040) | C | β 0.025 | 6E-42 | PubMed |
| Red blood cell count | C | β 0.025 | 3E-40 | PubMed |
| Monocyte side fluorescence | C | β 0.09 | 2E-35 | PubMed |
| Red blood cell count | C | β 0.026 | 1E-30 | PubMed |
| Mean corpuscular haemoglobin (UKB data field 30050) | C | β 0.02 | 9E-29 | PubMed |
| Red blood cell erythrocyte count (UKB data field 30010) | C | β 0.018 | 2E-28 | PubMed |
| Mean corpuscular volume | G | OR 0.12 | 2E-28 | PubMed |
| Mean sphered cell volume (UKB data field 30270) | C | β 0.021 | 3E-28 | PubMed |
| Red blood cell count | C | β 0.011 | 6E-22 | PubMed |
| FLT3LG protein levels | C | β 0.041 | 2E-15 | PubMed |
| IL15 protein levels | C | β 0.042 | 4E-14 | PubMed |
| CLEC5A protein levels | C | β 0.035 | 2E-12 | PubMed |
| White blood cell count (monocyte) | C | β 0.028 | 8E-10 | PubMed |
| Inflammatory bowel disease | G | OR 1.05 | 2E-9 | PubMed |
| Peripheral blood CD34+ cell levels | G | β 0.075 | 4E-9 | PubMed |
| Inflammatory bowel disease | — | β 0.053 | 2E-8 | PubMed |
| Monocyte count | C | β 0.034 | 7E-8 | PubMed |
| Inflammatory bowel disease | — | — | 1E-6 | PubMed |
| Monocyte-lymphocyte ratio | — | — | 2E-6 | PubMed |
Sources
- dbSNP: rs1991866 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies