Genetic variant
rs1966265
rs1966265 is a single-letter difference in human DNA, on chromosome 5. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs1966265 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
Association of a FGFR-4 Gene Polymorphism with Bronchopulmonary Dysplasia and Neonatal Respiratory Distress
From SNPedia
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs1966265, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs1966265
- Position
- chr5:177089630
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Height | A | β 0.047 | 1E-300 | PubMed |
| Height | A | β 0.049 | 1E-300 | PubMed |
| Height | A | β 0.049 | 4E-80 | PubMed |
| Waist circumference adjusted for body mass index | A | β 0.044 | 2E-34 | PubMed |
| Waist-hip index | A | β 0.042 | 3E-31 | PubMed |
| Waist-to-hip ratio adjusted for BMI | A | β 0.038 | 3E-26 | PubMed |
| Waist circumference adjusted for body mass index | A | β 0.034 | 2E-25 | PubMed |
| Hip shape (DXA scan) | T | OR 0.13 | 4E-20 | PubMed |
| Waist-to-hip ratio adjusted for BMI (additive genetic model) | A | β 0.023 | 2E-19 | PubMed |
| Height | A | β 0.022 | 2E-19 | PubMed |
| FVC | — | — | 1E-18 | PubMed |
| Waist-to-hip ratio adjusted for BMI (additive genetic model) | A | β 0.022 | 8E-17 | PubMed |
| Forced expiratory volume (baseline) | G | β 0.015 | 2E-14 | PubMed |
| Hip index | A | β 0.028 | 4E-14 | PubMed |
| A body shape index | A | β 0.026 | 5E-13 | PubMed |
| Multi-trait sex score | — | — | 5E-13 | PubMed |
| Waist-to-hip ratio adjusted for BMI (additive genetic model) | A | β 0.026 | 5E-13 | PubMed |
| A body shape index | A | β 0.023 | 3E-12 | PubMed |
| Height | — | β 0.02 | 3E-12 | PubMed |
| Type 2 diabetes | A | β 0.047 | 7E-12 | PubMed |
Sources
- dbSNP: rs1966265 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies