Genetic variant
rs1899951
rs1899951 is a single-letter difference in human DNA, on chromosome 3. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs1899951 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
Associated with risk of lung cancer in a Chinese population
From SNPedia
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs1899951, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs1899951
- Position
- chr3:12353341
Genome-wide association studies (18)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Body composition (MOSTest) | — | OR 13.82 | 2E-43 | PubMed |
| Triglyceride levels | T | β 0.039 | 9E-38 | PubMed |
| Type 2 diabetes | T | OR 0.11 | 2E-24 | PubMed |
| Calcium levels | T | β 0.035 | 3E-21 | PubMed |
| Valine levels | T | β 0.03 | 3E-20 | PubMed |
| Triglyceride levels | — | β 0.027 | 1E-11 | PubMed |
| Cholesteryl esters to total lipids ratio in large VLDL | C | β 0.037 | 6E-10 | PubMed |
| Cholesterol to total lipids ratio in large VLDL | C | β 0.037 | 1E-9 | PubMed |
| Serum urate levels | T | β 0.024 | 4E-9 | PubMed |
| Body mass index | T | β 0.024 | 6E-9 | PubMed |
| Body mass index | C | β 0.015 | 7E-9 | PubMed |
| Cholesterol to total lipids ratio in medium VLDL | C | β 0.034 | 1E-8 | PubMed |
| Cholesteryl esters to total lipids ratio in medium VLDL | C | β 0.033 | 2E-8 | PubMed |
| Triglycerides to total lipids ratio in medium VLDL | C | β 0.033 | 2E-8 | PubMed |
| Cholesterol to total lipids ratio in very large VLDL | C | β 0.034 | 2E-8 | PubMed |
| Cholesteryl esters to total lipids ratio in very large VLDL | C | β 0.034 | 2E-8 | PubMed |
| Free cholesterol to total lipids ratio in medium VLDL | C | β 0.033 | 3E-8 | PubMed |
| Cholesteryl esters to total lipids ratio in small VLDL | C | β 0.034 | 3E-8 | PubMed |
Sources
- dbSNP: rs1899951 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies