Genetic variant
rs186696265
rs186696265 is a single-letter difference in human DNA, on chromosome 6. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs186696265 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
A genome-wide association meta-analysis on lipoprotein(a) concentrations adjusted for apolipoprotein(a) isoforms.
From SNPedia
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs186696265, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs186696265
- Position
- chr6:160690668
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Lipoprotein (a) levels | T | OR 64.74 | 4E-231 | PubMed |
| Lipoprotein(a) levels adjusted for apolipoprotein(a) isoforms | T | OR 49.06 | 2E-207 | PubMed |
| Coronary artery disease | T | OR 1.68 | 9E-116 | PubMed |
| Coronary artery disease | T | OR 0.55 | 5E-92 | PubMed |
| Low density lipoprotein cholesterol levels | C | OR 0.38 | 4E-69 | PubMed |
| Total cholesterol levels | C | OR 0.36 | 8E-64 | PubMed |
| Phospholipids to Total Lipids in Chylomicrons and Extremely Large VLDL percentage | T | OR 0.18 | 3E-47 | PubMed |
| Triglyceride levels | T | OR 0.15 | 9E-45 | PubMed |
| Linoleic acid levels | C | OR 0.23 | 3E-40 | PubMed |
| Triglycerides in medium LDL (UKB data field 23543) | T | OR 0.26 | 1E-39 | PubMed |
| Triglyceride levels | C | OR 0.1 | 5E-36 | PubMed |
| Total omega-6 fatty acid levels | C | OR 0.21 | 5E-35 | PubMed |
| Coronary artery disease (MTAG) | T | OR 0.17 | 7E-34 | PubMed |
| Triglycerides in LDL (UKB data field 23409) | T | OR 0.21 | 8E-27 | PubMed |
| Triglycerides | T | OR 0.1 | 2E-26 | PubMed |
| Parental longevity (combined parental attained age, Martingale residuals) | C | β 0.08 | 8E-18 | PubMed |
| heart rate (HR, mean, inv-normal transformed) | C | β 0.095 | 1E-14 | PubMed |
| LDL cholesterol | T | OR 0.26 | 4E-14 | PubMed |
| Total phospholipids in lipoprotein particles (UKB data field 23411) | T | OR 0.14 | 7E-14 | PubMed |
| Lipoprotein phospholipase A2 activity in cardiovascular disease | T | OR 12.07 | 1E-12 | PubMed |
Sources
- dbSNP: rs186696265 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies