Genetic variant
rs1864163
rs1864163 is a single-letter difference in human DNA, on chromosome 16. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs1864163 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
G allele is associated with 4.12mg/dl increase in HDL cholesterol (good cholesterol). [GWAS:HDL cho...
From SNPedia
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs1864163, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs1864163
- Position
- chr16:56963321
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Free Cholesterol to Total Lipids in Very Large HDL percentage | A | OR 0.23 | 8E-1213 | PubMed |
| Free Cholesterol to Total Lipids in Very Large HDL percentage | A | OR 0.19 | 2E-682 | PubMed |
| Phospholipids to Total Lipids in Very Large HDL percentage | A | OR 0.15 | 8E-523 | PubMed |
| Phospholipids to Total Lipids in Very Large HDL percentage | A | β 0.094 | 2E-165 | PubMed |
| High density lipoprotein cholesterol levels | — | OR 2.37 | 5E-79 | PubMed |
| Total cholesterol to total lipids ratio in medium VLDL | A | β 0.069 | 2E-50 | PubMed |
| Cholesteryl esters to total lipids ratio in medium VLDL | A | β 0.068 | 2E-49 | PubMed |
| HDL cholesterol | G | OR 4.12 | 7E-39 | PubMed |
| Phospholipids in very small VLDL | A | β 0.058 | 7E-36 | PubMed |
| Total esterified cholesterol levels | G | β 0.055 | 1E-33 | PubMed |
| Polyunsaturated fatty acid levels | A | — | 4E-29 | PubMed |
| Multi-trait sum score | — | — | 4E-28 | PubMed |
| Apolipoprotein B levels | A | β 0.048 | 2E-25 | PubMed |
| Lipid metabolism phenotypes | — | OR 27.87 | 3E-25 | PubMed |
| Total cholesterol levels | G | β 0.046 | 2E-24 | PubMed |
| Linoleic acid levels | A | — | 2E-23 | PubMed |
| Cholesteryl esters to total lipids ratio in small VLDL | A | β 0.045 | 2E-22 | PubMed |
| Total fatty acid levels | A | — | 8E-22 | PubMed |
| Age-related macular degeneration or COVID-19 critical illness (MTAG) | — | β 0.08 | 2E-20 | PubMed |
| Age-related macular degeneration or COVID-19 infection (MTAG) | — | β 0.08 | 3E-20 | PubMed |
Sources
- dbSNP: rs1864163 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies