Genetic variant

rs1801689

rs1801689 is a single-letter difference in human DNA, on chromosome 17. Carrying it does not, on its own, mean you have or will develop any condition.

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What is this?

Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs1801689 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.

We hold only the basic reference record for this variant: its ID and position. Many catalogued variants have never been linked to anything.

Why might it matter?

ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.

Do I have this variant?

If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs1801689, if your test read this position.

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Connect this with your blood results

A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.

Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.

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What should I do next?

  1. Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
  2. Put it in context. Add your blood results, so the variant can be read against what your body is doing.
  3. Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
  4. Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
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This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.

Technical details

dbSNP ID
rs1801689
Position
chr17:66214462

Genome-wide association studies (20)

TraitRisk alleleOR / betaP-valueStudy
Beta-2-glycoprotein 1 levels A OR 1.66 1E-423 PubMed
IL18R1 protein levels C OR 0.24 1E-251 PubMed
TXNDC15 protein levels C OR 0.44 6E-239 PubMed
PRSS53 protein levels C OR 0.31 1E-233 PubMed
CD99/CD99L2 protein level ratio — OR 0.48 6E-178 PubMed
CD99L2 protein levels C OR 0.43 2E-152 PubMed
HSD11B1 protein levels C OR 0.38 2E-132 PubMed
Cholesterol to Total Lipids in Chylomicrons and Extremely Large VLDL percentage C OR 0.14 3E-126 PubMed
Cholesterol to Total Lipids in Large VLDL percentage C OR 0.14 5E-125 PubMed
Average diameter for VLDL particles C OR 0.13 3E-123 PubMed
Triglycerides to Total Lipids in Chylomicrons and Extremely Large VLDL percentage C OR 0.14 6E-123 PubMed
ENTPD5 protein levels C OR 0.35 2E-119 PubMed
Cholesteryl Esters to Total Lipids in Large VLDL percentage C OR 0.13 5E-119 PubMed
HYOU1/PTPRF protein level ratio — OR 0.45 1E-117 PubMed
Cholesteryl Esters to Total Lipids in Chylomicrons and Extremely Large VLDL percentage C OR 0.14 5E-113 PubMed
DnaJ homolog subfamily B member 9 levels A OR 0.83 2E-102 PubMed
NAD-dependent protein deacetylase sirtuin-2 levels C OR 0.94 1E-100 PubMed
Triglyceride levels in chylomicrons and extremely large VLDL C OR 0.12 1E-100 PubMed
Triglycerides to Total Lipids in Large VLDL percentage C OR 0.13 2E-100 PubMed
ATP-dependent RNA helicase DHX8 levels A OR 0.84 4E-100 PubMed

Sources