Genetic variant
rs1801282
rs1801282 is a single-letter difference in human DNA, on chromosome 3. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs1801282 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
rs1801282, also known as Pro12Ala, is a common SNP in the peroxisome proliferator-activated receptor...
From SNPedia
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs1801282, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs1801282
- Position
- chr3:12351626
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Sex hormone-binding globulin levels adjusted for BMI | G | β 0.022 | 3E-67 | PubMed |
| Albumin levels | C | β 0.048 | 9E-55 | PubMed |
| Sex hormone-binding globulin levels adjusted for BMI | G | β 0.024 | 9E-43 | PubMed |
| Serum albumin levels | G | β 0.048 | 2E-41 | PubMed |
| Sex hormone-binding globulin levels | G | β 0.018 | 1E-37 | PubMed |
| Type 2 diabetes | G | OR 0.16 | 5E-37 | PubMed |
| Gamma glutamyl transferase levels | C | β 0.037 | 7E-37 | PubMed |
| Body fat percentage (adjusted for testosterone and SHBG) | — | OR 0.37 | 2E-32 | PubMed |
| Glycine levels | G | β 0.03 | 1E-31 | PubMed |
| Total protein levels (UKB data field 30860) | G | β 0.036 | 3E-31 | PubMed |
| Albumin (maximum, inv-norm transformed) | C | β 0.047 | 5E-30 | PubMed |
| Diabetes / "Sugar" | C | β 0.092 | 5E-30 | PubMed |
| Sex hormone-binding globulin levels | — | β 0.051 | 3E-28 | PubMed |
| Serum total protein levels | G | β 0.039 | 2E-26 | PubMed |
| Body mass index | G | β 0.022 | 5E-26 | PubMed |
| Triglyceride levels | G | β 0.027 | 5E-26 | PubMed |
| Calcium levels (UKB data field 30680) | G | β 0.033 | 2E-25 | PubMed |
| Weight | C | β 0.026 | 4E-23 | PubMed |
| Fasting insulin | G | β 0.031 | 4E-23 | PubMed |
| Sex hormone-binding globulin levels | G | β 0.02 | 8E-23 | PubMed |
Sources
- dbSNP: rs1801282 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies