Genetic variant

rs1801274

rs1801274 is a single-letter difference in human DNA, on chromosome 1. Carrying it does not, on its own, mean you have or will develop any condition.

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What is this?

Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs1801274 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.

rs1801274 is a SNP in the Fc fragment of IgG, low affinity IIa, receptor (CD32) FCGR2A gene. rs18012...

From SNPedia

Why might it matter?

ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.

Do I have this variant?

If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs1801274, if your test read this position.

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Connect this with your blood results

A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.

Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.

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What should I do next?

  1. Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
  2. Put it in context. Add your blood results, so the variant can be read against what your body is doing.
  3. Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
  4. Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
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This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.

Technical details

dbSNP ID
rs1801274
Position
chr1:161509955

Genome-wide association studies (20)

TraitRisk alleleOR / betaP-valueStudy
Low affinity immunoglobulin gamma Fc region receptor II-a levels (FCGR2A.3309.2.2) G OR 1.24 1E-2102 PubMed
FCGR2A/FCGR2B protein level ratio — OR 0.55 4E-1407 PubMed
Low affinity immunoglobulin gamma Fc region receptor II-b (analyte X3310.62) levels A OR 1.05 5E-616 PubMed
Low affinity immunoglobulin gamma Fc region receptor II-a levels G OR 1.24 4E-303 PubMed
Low affinity immunoglobulin gamma Fc region receptor II-b levels G OR 0.81 4E-206 PubMed
Low affinity immunoglobulin gamma Fc region receptor II-a level in Chronic kidney disease with hypertension and no diabetes (3309_2) G OR 1.16 1E-165 PubMed
CD40 on CD14- CD16+ monocyte G OR 0.53 1E-90 PubMed
CD40 on monocytes G OR 0.51 7E-84 PubMed
Low affinity immunoglobulin gamma Fc region receptor II-b level in Chronic kidney disease with hypertension and no diabetes (3310_62) G OR 0.94 8E-72 PubMed
CD40 on CD14+ CD16+ monocyte G OR 0.46 2E-70 PubMed
CX3CR1 on CD14+ CD16+ monocyte G OR 0.46 3E-69 PubMed
FCGR2B protein levels G OR 0.95 8E-67 PubMed
CX3CR1 on CD14+ CD16- monocyte G OR 0.45 2E-64 PubMed
CD40 on CD14+ CD16- monocyte G OR 0.44 2E-62 PubMed
CD11b on CD14+ monocyte G OR 0.62 6E-61 PubMed
CD64 on CD14+ CD16- monocyte G OR 0.43 1E-59 PubMed
CD33dim HLA DR+ CD11b+ %CD33dim HLA DR+ G OR 0.55 3E-54 PubMed
CD33dim HLA DR+ CD11b- %CD33dim HLA DR+ G OR 0.55 3E-54 PubMed
CX3CR1 on monocyte G OR 0.41 4E-54 PubMed
CD64 on monocyte G OR 0.39 8E-50 PubMed

Sources