RS1801272 CYP2A6

Drug Response Chr 19:40848627 snv missense variant

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What This Variant Does

"minor form is a slow metaboliser according to pharmgkb [OMIM:?] [GWAS:Smoking behavior]

Associated Conditions

Warfarin response

NICOTINE

POOR METABOLISM OF

Warfarin response

NICOTINE

POOR METABOLISM OF

GWAS Studies (4)

Trait	Risk Allele	OR / Beta	P-value	Study
C-reactive protein levels	A	β: 0.053	3E-14	PubMed
C-reactive protein levels (UKB data field 30710)	T	β: 0.046	4E-14	PubMed
C-reactive protein levels	A	β: 0.048	1E-12	PubMed
Smoking behavior	T	OR: 9.4	5E-6	PubMed

Population Frequencies

gnomAD ALL

97.5%

1kG AFR

0.1%

1kG ALL

99.1%

1kG AMR

0.7%

1kG EAS

100%

1kG EUR

3.4%

1kG SAS

0.6%