Genetic variant

rs1800961

rs1800961 is a single-letter difference in human DNA, on chromosome 20. Carrying it does not, on its own, mean you have or will develop any condition.

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What is this?

Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs1800961 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.

per the 23andMe blog, the minor allele of this SNP (T) was associated with decreased HDL cholesterol...

From SNPedia

Why might it matter?

ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.

Do I have this variant?

If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs1800961, if your test read this position.

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Connect this with your blood results

A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.

Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.

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What should I do next?

  1. Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
  2. Put it in context. Add your blood results, so the variant can be read against what your body is doing.
  3. Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
  4. Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
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This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.

Technical details

dbSNP ID
rs1800961
Position
chr20:44413724

Genome-wide association studies (20)

TraitRisk alleleOR / betaP-valueStudy
High density lipoprotein cholesterol levels — — 1E-268 PubMed
high density lipoprotein cholesterol (HDLC, mean, inv-norm transformed) C OR 0.28 3E-236 PubMed
high density lipoprotein cholesterol (HDLC, minimm, inv-norm transformed) C OR 0.26 1E-211 PubMed
high density lipoprotein cholesterol (HDLC, maximum, inv-norm transformed) C OR 0.26 1E-208 PubMed
High-density lipoprotein levels T OR 0.19 9E-190 PubMed
High density lipoprotein cholesterol levels T OR 0.13 3E-157 PubMed
Apolipoprotein A1 levels C OR 0.15 2E-152 PubMed
Apolipoprotein A levels (UKB data field 30630) T OR 0.13 7E-142 PubMed
HDL cholesterol levels C OR 0.14 1E-140 PubMed
Concentration of HDL particles T OR 0.13 2E-134 PubMed
Haematocrit percentage (UKB data field 30030) T OR 0.12 2E-134 PubMed
Total concentration of lipoprotein particles T OR 0.13 2E-123 PubMed
Apolipoprotein A1 levels T OR 0.12 4E-121 PubMed
high density lipoprotein cholesterol (HDLC, mean, inv-norm transformed) C OR 0.23 4E-119 PubMed
Cholesterol in Medium HDL T OR 0.12 4E-117 PubMed
Free cholesterol in medium HDL T OR 0.12 1E-116 PubMed
Cholesteryl Esters in Medium HDL T OR 0.12 5E-115 PubMed
high density lipoprotein cholesterol (HDLC, maximum, inv-norm transformed) C OR 0.22 3E-113 PubMed
Total cholesterol levels — — 2E-111 PubMed
Concentration of medium HDL particles T OR 0.12 1E-110 PubMed

Sources