Genetic variant
rs1800759
rs1800759 is a single-letter difference in human DNA, on chromosome 4. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs1800759 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
rs1800759 is a SNP in the promoter (regulatory region) of the alcohol dehydrogenase 4 (ADH4) gene. I...
From SNPedia
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs1800759, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs1800759
- Position
- chr4:99144358
Genome-wide association studies (19)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| ADH4 protein levels | G | OR 0.12 | 2E-97 | PubMed |
| Tyrosine levels | G | β 0.04 | 7E-75 | PubMed |
| Serum alkaline phosphatase levels | T | OR 13.2 | 5E-40 | PubMed |
| FUT3 or FUT5 protein levels | G | β 0.055 | 6E-32 | PubMed |
| Protein quantitative trait loci (liver) | T | OR 0.26 | 2E-28 | PubMed |
| Citrate levels | G | β 0.02 | 2E-27 | PubMed |
| Aspartate aminotransferase levels (UKB data field 30650) | G | β 0.019 | 7E-24 | PubMed |
| Total bilirubin levels (UKB data field 30840) | G | β 0.014 | 2E-20 | PubMed |
| Mean platelet thrombocyte volume (UKB data field 30100) | G | β 0.015 | 4E-19 | PubMed |
| CD163 protein levels | G | β 0.046 | 6E-19 | PubMed |
| Alcohol dehydrogenase 4 levels | T | OR 0.11 | 3E-16 | PubMed |
| BTD protein levels | G | β 0.039 | 2E-15 | PubMed |
| ADA2 protein levels | G | β 0.04 | 2E-14 | PubMed |
| Aspartate aminotransferase levels | T | OR 7.6 | 3E-14 | PubMed |
| IL27 protein levels | G | β 0.035 | 2E-12 | PubMed |
| Free Cholesterol to Total Lipids in Very Large VLDL percentage | G | β 0.01 | 5E-11 | PubMed |
| Cholesteryl Esters to Total Lipids in Large VLDL percentage | G | β 0.01 | 2E-10 | PubMed |
| Blood protein levels | G | OR 0.16 | 4E-10 | PubMed |
| Insomnia | T | β 0.005 | 4E-8 | PubMed |
Sources
- dbSNP: rs1800759 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies