RS1800588 LIPC
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What This Variant Does
"rs1800588, also known as the -514C/T polymorphism of the LIPC gene, may influence the levels of the ..."
Associated Conditions
High density lipoprotein cholesterol level quantitative trait locus 12
High density lipoprotein cholesterol level quantitative trait locus 12
GWAS Studies (20)
| Trait | Risk Allele | OR / Beta | P-value | Study |
|---|---|---|---|---|
| Free Cholesterol to Total Lipids in Small HDL percentage | T | OR: 0.27 | 3E-1443 | PubMed |
| Phospholipids to Total Lipids in Large LDL percentage | T | OR: 0.23 | 7E-1012 | PubMed |
| Free Cholesterol to Total Lipids in Small HDL percentage | T | OR: 0.23 | 7E-803 | PubMed |
| HDL cholesterol levels | C | OR: 0.12 | 2E-566 | PubMed |
| Triglyceride levels in HDL | T | OR: 0.23 | 3E-544 | PubMed |
| Phospholipids to Total Lipids in Large LDL percentage | T | OR: 0.17 | 2E-463 | PubMed |
| Phosphatidylcholine and other choline levels | T | OR: 0.17 | 1E-300 | PubMed |
| Total phosphoglycerides levels | T | OR: 0.17 | 5E-281 | PubMed |
| Total cholines levels | T | OR: 0.16 | 2E-262 | PubMed |
| Total cholesterol in HDL3 | T | OR: 0.16 | 6E-256 | PubMed |
| Total fatty acid levels | T | — | 4E-241 | PubMed |
| Saturated fatty acids levels | T | — | 1E-229 | PubMed |
| Total fatty acid levels | T | — | 2E-209 | PubMed |
| Linoleic acid levels | T | — | 2E-200 | PubMed |
| Cholesterol in large HDL (UKB data field 23561) | T | OR: 0.15 | 7E-198 | PubMed |
| Saturated fatty acids levels | T | — | 6E-197 | PubMed |
| High density lipoprotein cholesterol levels | — | OR: 0.14 | 3E-191 | PubMed |
| Total fatty acids | T | OR: 0.13 | 5E-170 | PubMed |
| Saturated fatty acids | T | OR: 0.13 | 4E-167 | PubMed |
| Phospholipids to Total Lipids in Large HDL percentage | T | β: 0.092 | 3E-165 | PubMed |
Population Frequencies
gnomAD ALL
72.8%
1kG AFR
44%
1kG ALL
38.6%
1kG AMR
42.2%
1kG EAS
60%
1kG EUR
20.9%
1kG SAS
70.4%
Other Variants in LIPC