Genetic variant
rs1800437
rs1800437 is a single-letter difference in human DNA, on chromosome 19. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs1800437 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
SNP rs1800437, located in the coding region of the GIPR gene and known as Glu354Gln, shows a margina...
From SNPedia
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs1800437, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs1800437
- Position
- chr19:45678134
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Body mass index | G | β 0.033 | 5E-90 | PubMed |
| Body mass index | C | β 0.034 | 3E-59 | PubMed |
| Body mass index (BMI, maximum, inv-normal transformed) | G | β 0.064 | 3E-53 | PubMed |
| Body mass index (BMI, mean, inv-normal transformed) | G | β 0.063 | 7E-53 | PubMed |
| Weight (maximum, inv-normal transformed) | G | β 0.063 | 3E-50 | PubMed |
| Weight (mean, inv-normal transformed) | G | β 0.062 | 3E-49 | PubMed |
| Body mass index (BMI, minimum, inv-normal transformed) | G | β 0.055 | 2E-45 | PubMed |
| Body mass index | G | β 0.031 | 6E-45 | PubMed |
| Weight (minimum, inv-normal transformed) | G | β 0.055 | 5E-43 | PubMed |
| Blood urea nitrogen (BUN, mean, inv-norm transformed) | G | β 0.04 | 2E-36 | PubMed |
| Obesity (PheCode 278.1) | G | β 0.058 | 5E-34 | PubMed |
| Overweight, obesity and other hyperalimentation (PheCode 278) | G | β 0.055 | 2E-29 | PubMed |
| Blood urea nitrogen (BUN, minimum, inv-norm transformed) | G | β 0.034 | 2E-28 | PubMed |
| Blood urea nitrogen (BUN, maximum, inv-norm transformed) | G | β 0.033 | 3E-28 | PubMed |
| What is your weight? (pounds, inv-normal transformed) | G | β 0.049 | 2E-27 | PubMed |
| Morbid obesity (PheCode 278.11) | G | β 0.085 | 7E-27 | PubMed |
| Two-hour glucose | C | OR 0.1 | 5E-26 | PubMed |
| Waist circumference | — | — | 1E-24 | PubMed |
| Two-hour glucose | C | OR 0.1 | 3E-23 | PubMed |
| BMI and adiposity (confirmatory factor analysis Factor 7) | — | — | 1E-22 | PubMed |
Sources
- dbSNP: rs1800437 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies