RS1799986 LRP1

Health Risk Chr 12:57141482 snv missense variant

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What This Variant Does

"Genetic Interaction between Tau and the Apolipoprotein E Receptor LRP1 Increases Alzheimer's Disease Risk"

Associated Conditions

Keratosis pilaris

LRP1-related disorder

Keratosis pilaris atrophicans

Developmental dysplasia of the hip 3

Keratosis pilaris

LRP1-related disorder

Keratosis pilaris atrophicans

Developmental dysplasia of the hip 3

GWAS Studies (3)

Trait	Risk Allele	OR / Beta	P-value	Study
INHBC protein levels	T	β: 0.095	1E-44	PubMed
Atopic dermatitis	—	β: 0.067	7E-11	PubMed
Height	T	β: 0.006	1E-10	PubMed

Population Frequencies

gnomAD ALL

14.4%

1kG AFR

5.2%

1kG ALL

90.7%

1kG AMR

92.8%

1kG EAS

93.1%

1kG EUR

15.1%

1kG SAS

13%

Other Variants in LRP1