Genetic variant
rs1799884
rs1799884 is a single-letter difference in human DNA, on chromosome 7. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs1799884 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
rs1799884, known also as the -30 SNP of the GCK gene, has been associated with type-2 diabetes. This...
From SNPedia
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs1799884, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs1799884
- Position
- chr7:44189469
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Glucose (fasting status unknown, mean, inv-norm transformed) | C | β 0.094 | 5E-162 | PubMed |
| Glucose (fasting status unknown, minimum, inv-norm transformed) | C | β 0.069 | 4E-134 | PubMed |
| Glucose (fasting status unknown, maximum, inv-norm transformed) | C | β 0.065 | 7E-84 | PubMed |
| Abnormal glucose (PheCode 250.4) | C | OR 0.11 | 1E-68 | PubMed |
| Hemoglobin A1c (HbA1c, minimum, inv-norm transformed) | C | β 0.065 | 1E-66 | PubMed |
| Hemoglobin A1c (HbA1c, mean, inv-norm transformed) | C | β 0.063 | 1E-58 | PubMed |
| Hemoglobin A1c (HbA1c, maximum, inv-norm transformed) | C | β 0.059 | 1E-53 | PubMed |
| Impaired fasting glucose (PheCode 250.41) | C | OR 0.12 | 5E-48 | PubMed |
| Glucose (fasting status unknown, mean, inv-norm transformed) | C | β 0.084 | 5E-46 | PubMed |
| Glucose (fasting status unknown, minimum, inv-norm transformed) | C | β 0.062 | 3E-29 | PubMed |
| Fasting glucose | T | β 0.06 | 4E-28 | PubMed |
| Fasting blood glucose | T | OR 0.14 | 8E-27 | PubMed |
| Glucose (fasting status unknown, maximum, inv-norm transformed) | C | β 0.062 | 4E-26 | PubMed |
| Fasting blood glucose | — | OR 0.12 | 2E-25 | PubMed |
| Glucose (fasting status unknown, mean, inv-norm transformed) | C | β 0.074 | 4E-24 | PubMed |
| Glycated hemoglobin levels | T | β 0.033 | 2E-23 | PubMed |
| Glycated hemoglobin levels | T | OR 0.12 | 2E-22 | PubMed |
| Hemoglobin A1c levels | T | OR 0.11 | 3E-22 | PubMed |
| Multi-trait sum score | — | — | 8E-21 | PubMed |
| Glycated hemoglobin levels | T | β 0.04 | 1E-20 | PubMed |
Sources
- dbSNP: rs1799884 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies