Genetic variant
rs1776897
rs1776897 is a single-letter difference in human DNA, on chromosome 6. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs1776897 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
The role of height-associated loci identified in genome wide association studies in the determinatio...
From SNPedia
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs1776897, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs1776897
- Position
- chr6:34227234
Genome-wide association studies (12)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Height | — | — | 2E-235 | PubMed |
| Height | T | β 0.088 | 2E-29 | PubMed |
| Height | — | β 0.058 | 9E-20 | PubMed |
| Waist circumference adjusted for BMI in non-smokers | T | β 0.056 | 2E-14 | PubMed |
| Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) | T | — | 1E-13 | PubMed |
| Height | — | OR 0.12 | 8E-11 | PubMed |
| Multi-trait sum score | — | — | 3E-9 | PubMed |
| Height | C | OR 8.8 | 1E-8 | PubMed |
| Waist-to-hip ratio adjusted for body mass index | G | β 0.043 | 2E-7 | PubMed |
| Waist circumference adjusted for body mass index | T | β 0.048 | 8E-7 | PubMed |
| Height | T | OR 0.11 | 7E-6 | PubMed |
| Waist circumference adjusted for BMI (adjusted for smoking behaviour) | T | β 0.042 | 7E-6 | PubMed |
Sources
- dbSNP: rs1776897 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies