RS17486278 Unknown gene
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What This Variant Does
"Variants in nicotinic receptors and risk for nicotine dependence. A candidate gene approach identifi..."
GWAS Studies (20)
| Trait | Risk Allele | OR / Beta | P-value | Study |
|---|---|---|---|---|
| Cancer of bronchus; lung (PheCode 165.1) | A | OR: 0.21 | 3E-65 | PubMed |
| Cancer within the respiratory system (PheCode 165) | A | OR: 0.2 | 8E-62 | PubMed |
| Emphysema (PheCode 496.1) | A | OR: 0.19 | 4E-46 | PubMed |
| Obstructive chronic bronchitis (PheCode 496.21) | A | OR: 0.14 | 4E-45 | PubMed |
| Abdominal aortic aneurysm | — | OR: 0.1 | 2E-35 | PubMed |
| Chronic obstructive pulmonary disease | C | OR: 1.18 | 2E-28 | PubMed |
| Respiratory failure, insufficiency, arrest (PheCode 509) | A | β: 0.077 | 8E-21 | PubMed |
| Post bronchodilator FEV1/FVC ratio | A | β: 0.017 | 4E-20 | PubMed |
| Atherosclerosis of the extremities (PheCode 440.2) | A | OR: 0.1 | 5E-20 | PubMed |
| Atherosclerosis (PheCode 440) | A | β: 0.088 | 1E-18 | PubMed |
| Post bronchodilator FEV1 | A | β: 0.079 | 3E-18 | PubMed |
| Lung cancer | C | OR: 1.25 | 2E-17 | PubMed |
| Lung cancer | C | OR: 0.15 | 3E-17 | PubMed |
| Atherosclerosis of native arteries of the extremities with intermittent claudication (PheCode 440.22) | A | OR: 0.12 | 5E-17 | PubMed |
| How many years have you or did you smoke cigarettes? (inv-normal transformed) | A | β: 0.033 | 3E-16 | PubMed |
| Peripheral vascular disease | A | β: 0.061 | 3E-16 | PubMed |
| Respiratory failure (PheCode 509.1) | A | β: 0.075 | 3E-16 | PubMed |
| Abdominal aortic aneurysm (PheCode 442.11) | A | β: 0.098 | 4E-16 | PubMed |
| Biological Sibling: Cancer, Lung | A | OR: 0.11 | 2E-15 | PubMed |
| Chronic airway obstruction (PheCode 496) | A | β: 0.096 | 1E-14 | PubMed |