Genetic variant
rs17482753
rs17482753 is a single-letter difference in human DNA, on chromosome 8. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs17482753 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
rs17482753 increases susceptibility to Elevated HDL-Cholesterol for carriers of the T allele rs17482...
From SNPedia
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs17482753, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs17482753
- Position
- chr8:19975135
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Triglycerides | G | OR 0.19 | 3E-199 | PubMed |
| High density lipoprotein cholesterol levels | G | OR 0.14 | 2E-130 | PubMed |
| Free Cholesterol to Total Lipids in Very Large VLDL percentage | T | β 0.07 | 3E-97 | PubMed |
| Omega-6 fatty acids to omega-3 fatty acids ratio | T | β 0.05 | 5E-65 | PubMed |
| Free Cholesterol to Total Lipids in Chylomicrons and Extremely Large VLDL percentage | T | β 0.05 | 2E-46 | PubMed |
| High density lipoprotein cholesterol levels | T | OR 4.97 | 2E-41 | PubMed |
| Triglyceride levels | T | OR 12.82 | 8E-41 | PubMed |
| Cholesterol to Total Lipids in Chylomicrons and Extremely Large VLDL percentage | T | β 0.04 | 1E-39 | PubMed |
| Triglyceride levels | T | OR 10.83 | 6E-39 | PubMed |
| Cholesteryl esters to total lipids in small VLDL percentage (UKB data field 23601) | T | OR 0.1 | 2E-38 | PubMed |
| High density lipoprotein cholesterol levels | T | OR 2.59 | 5E-38 | PubMed |
| Triglycerides to total lipids ratio in chylomicrons and extremely large VLDL | T | β 0.087 | 2E-34 | PubMed |
| Triglyceride levels | — | β 0.088 | 2E-32 | PubMed |
| Metabolic syndrome | G | OR 0.2 | 9E-28 | PubMed |
| High density lipoprotein cholesterol levels | — | OR 2.03 | 2E-22 | PubMed |
| Cholesterol | T | β 0.042 | 3E-18 | PubMed |
| Low high density lipoprotein cholesterol levels | — | — | 9E-17 | PubMed |
| Sphingomyelin_36:0_[M+H]1+ levels | T | OR 0.15 | 1E-14 | PubMed |
| Sphingomyelin_36:1_[M+H]1+ levels | T | OR 0.15 | 2E-14 | PubMed |
| Sphingomyelin(42:3)_[M+H]1+ levels | C | OR 0.2 | 6E-14 | PubMed |
Sources
- dbSNP: rs17482753 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies