Genetic variant
rs174583
rs174583 is a single-letter difference in human DNA, on chromosome 11. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs174583 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
We hold only the basic reference record for this variant: its ID and position. Many catalogued variants have never been linked to anything.
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs174583, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs174583
- Position
- chr11:61842278
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Lysophosphatidylethanolamine_22:4_[M-H]1- levels | T | OR 0.35 | 6E-272 | PubMed |
| Lysophosphatidylcholine_20:4_[M+H]1+ levels | T | OR 0.4 | 9E-253 | PubMed |
| Phosphatidylethanolamine_38:4_[M-H]1- levels | T | OR 0.22 | 3E-144 | PubMed |
| Cholesteryl ester_20:5_[M+NH4]1+ levels | T | OR 0.3 | 6E-139 | PubMed |
| Phosphatidylcholine_37:4_[M+H]1+/Phosphatidylethanolamine_40:4_[M+H]1+/Phosphatidate_42:5_[M+NH4]1+ levels | T | OR 0.37 | 9E-125 | PubMed |
| Fatty acid(20:4)_[M-H]1- levels | T | OR 0.18 | 3E-116 | PubMed |
| Phosphatidylcholine_38:5_[M+H]1+/Phosphatidylethanolamine_41:5_[M+H]1+/Phosphatidate_43:6_[M+NH4]1+ levels | T | OR 0.35 | 7E-113 | PubMed |
| Phosphatidylcholine_36:3_[M+H]1+/Phosphatidylethanolamine_39:3_[M+H]1+/Phosphatidate_41:4_[M+NH4]1+ levels | T | OR 0.33 | 1E-108 | PubMed |
| Diacylglycerol_38:3_[M+H-H2O]1+ levels | T | OR 0.17 | 2E-93 | PubMed |
| Phosphatidylcholine_35:3_[M+H]1+/Phosphatidylethanolamine_38:3_[M+H]1+/Phosphatidate_40:4_[M+NH4]1+ levels | T | OR 0.21 | 4E-90 | PubMed |
| Phosphatidylinositol_36:3_[M-H]1- levels | T | OR 0.22 | 7E-87 | PubMed |
| Phosphatidylcholine (18:0/20:2, 20:0/18:2, 18:1/20:1) levels | T | OR 0.31 | 1E-85 | PubMed |
| Phosphatidylethanolamine_39:4_[M-H]1- levels | T | OR 0.18 | 4E-77 | PubMed |
| Phosphatidylethanolamine_38:3_[M-H]1- levels | T | OR 0.15 | 8E-76 | PubMed |
| Phosphatidylcholine_34:2_[M+H]1+/Phosphatidylethanolamine_37:2_[M+H]1+/Phosphatidate_39:3_[M+NH4]1+ levels | T | OR 0.22 | 2E-75 | PubMed |
| Phosphatidylcholine_35:4_[M+H]1+/Phosphatidylethanolamine_38:4_[M+H]1+/Phosphatidate_40:5_[M+NH4]1+ levels | T | OR 0.22 | 3E-73 | PubMed |
| Phosphatidylethanolamine-O_40:5_[M-H]1-/Phosphatidylethanolamine-P_40:4_[M-H]1- levels | T | OR 0.16 | 3E-70 | PubMed |
| Phosphatidylcholine_31:2_[M+H]1+/Phosphatidylethanolamine_34:2_[M+H]1+/Phosphatidate_36:3_[M+NH4]1+ levels | T | OR 0.22 | 6E-70 | PubMed |
| Diacylglycerol_38:5_[M+H-H2O]1+ levels | T | OR 0.15 | 7E-70 | PubMed |
| Lysophosphatidylethanolamine_20:4_[M-H]1- levels | T | OR 0.21 | 2E-68 | PubMed |
Sources
- dbSNP: rs174583 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies