Genetic variant

rs174579

rs174579 is a single-letter difference in human DNA, on chromosome 11. Carrying it does not, on its own, mean you have or will develop any condition.

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What is this?

Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs174579 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.

Genetic loci associated with circulating phospholipid trans fatty acids: a meta-analysis of genome-wide association studies from the CHARGE Consortium

From SNPedia

Why might it matter?

ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.

Do I have this variant?

If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs174579, if your test read this position.

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Connect this with your blood results

A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.

Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.

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What should I do next?

  1. Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
  2. Put it in context. Add your blood results, so the variant can be read against what your body is doing.
  3. Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
  4. Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
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This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.

Technical details

dbSNP ID
rs174579
Position
chr11:61838141

Genome-wide association studies (20)

TraitRisk alleleOR / betaP-valueStudy
Phosphatidylcholine(36:3)_[M+OAc]1-/Phosphatidylserine(40:2)_[M-H]1- levels G β 0.074 9E-15 PubMed
Phosphatidylcholine(38:3)_[M+H]1+/Phosphatidylethanolamine(41:3)_[M+H]1+/Phosphatidate(43:4)_[M+NH4]1+ levels C β 0.044 9E-15 PubMed
Phosphatidylcholine(38:4)_[M+H]1+/Phosphatidylethanolamine(41:4)_[M+H]1+ levels C β 0.069 9E-15 PubMed
Phosphatidylcholine(38:5)_[M+H]1+/Phosphatidylethanolamine(41:5)_[M+H]1+/Phosphatidate(43:6)_[M+NH4]1+ levels G β 0.083 9E-15 PubMed
Phosphatidylcholine(37:4)_[M+H]1+/Phosphatidylethanolamine(40:4)_[M+H]1+/Phosphatidate(42:5)_[M+NH4]1+ levels T OR 0.15 9E-15 PubMed
Sphingomyelin(44:9)_[M+H]1- levels T β 0.072 9E-15 PubMed
Phosphatidate(43:4)_[M-H]1- levels G β 0.056 9E-15 PubMed
Phosphatidylcholine(36:3)_[M+H]1+/Phosphatidylethanolamine(39:3)_[M+H]1+/Phosphatidate(41:4)_[M+NH4]1+ levels A β 0.085 9E-15 PubMed
Phosphatidylcholine(40:5)_[M+H]1+ levels C β 0.055 9E-15 PubMed
Phosphatidylcholine(38:4)_[M+OAc]1-/Phosphatidylserine(42:3)_[M-H]1- levels G β 0.067 9E-15 PubMed
Phosphatidylcholine-O(36:5)_[M+H]1+/Phosphatidylcholine-P(36:4)_[M+H]1+ levels G β 0.052 9E-15 PubMed
Phosphatidylinositol(36:1)_[M+OAc]1- levels G β 0.059 9E-15 PubMed
Phosphatidylcholine(42:4)_[M+OAc]1- levels G β 0.045 9E-15 PubMed
Cholesteryl ester(20:4)_[M+NH4]1+ levels G β 0.076 9E-15 PubMed
Cholesteryl ester(20:5)_[M+NH4]1+ levels T β 0.08 9E-15 PubMed
Phosphatidylcholine(38:3)_[M+OAc]1-/Phosphatidylserine(42:2)_[M-H]1- levels C β 0.047 1E-14 PubMed
Lysophosphatidylcholine(20:4)_[M+H]1+ levels C β 0.042 1E-14 PubMed
Phosphatidylcholine(36:5)_[M+OAc]1-/Phosphatidylserine(40:4)_[M-H]1- levels C β 0.074 1E-14 PubMed
Phosphatidylinositol(38:4)_[M-H]1- levels C β 0.061 1E-14 PubMed
Phosphatidylcholine(40:5)_[M+OAc]1-/Phosphatidylserine(44:4)_[M-H]1- levels A β 0.097 1E-14 PubMed

Sources