Genetic variant
rs174574
rs174574 is a single-letter difference in human DNA, on chromosome 11. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs174574 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
We hold only the basic reference record for this variant: its ID and position. Many catalogued variants have never been linked to anything.
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs174574, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs174574
- Position
- chr11:61832870
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Estimated degree of unsaturation | A | OR 0.32 | 9E-1274 | PubMed |
| Phospholipids in very large HDL | A | OR 0.12 | 1E-197 | PubMed |
| Concentration of very large HDL particles | A | OR 0.12 | 1E-189 | PubMed |
| Total lipids in very large HDL | A | OR 0.12 | 2E-187 | PubMed |
| 1-arachidonoyl-GPA (20:4) levels | A | OR 0.3 | 8E-178 | PubMed |
| Mean diameter of HDL particles | A | OR 0.12 | 8E-174 | PubMed |
| Cholesteryl esters to total lipids ratio in small VLDL | A | OR 0.11 | 3E-169 | PubMed |
| Total cholesterol to total lipids ratio in small VLDL | A | OR 0.11 | 4E-169 | PubMed |
| Cholesteryl esters to total lipids ratio in medium VLDL | A | OR 0.11 | 4E-162 | PubMed |
| Free cholesterol in very large HDL | A | OR 0.11 | 8E-159 | PubMed |
| Total cholesterol levels in very large HDL | A | OR 0.11 | 4E-151 | PubMed |
| Cholesterol esters in very large HDL | A | OR 0.1 | 4E-143 | PubMed |
| Triglyceride levels | A | β 0.048 | 1E-142 | PubMed |
| Total cholesterol to total lipids ratio in very small VLDL | A | OR 0.1 | 2E-136 | PubMed |
| Total cholesterol to total lipids ratio in medium VLDL | A | β 0.099 | 1E-131 | PubMed |
| Cholesteryl Esters to Total Lipids in Medium HDL percentage | C | β 0.05 | 1E-127 | PubMed |
| Phosphatidylcholine (18:1_18:2) levels | A | OR 0.38 | 3E-114 | PubMed |
| Triglycerides | C | β 0.047 | 7E-110 | PubMed |
| Free cholesterol in large HDL | A | β 0.091 | 1E-109 | PubMed |
| Phosphatidylcholine (16:1_18:2) levels | A | OR 0.37 | 2E-105 | PubMed |
Sources
- dbSNP: rs174574 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies