Genetic variant

rs174553

rs174553 is a single-letter difference in human DNA, on chromosome 11. Carrying it does not, on its own, mean you have or will develop any condition.

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What is this?

Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs174553 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.

Association of fatty acid desaturase gene polymorphisms with blood lipid essential fatty acids and perinatal depression among Canadian women: a pilot study

From SNPedia

Why might it matter?

ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.

Do I have this variant?

If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs174553, if your test read this position.

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Connect this with your blood results

A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.

Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.

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What should I do next?

  1. Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
  2. Put it in context. Add your blood results, so the variant can be read against what your body is doing.
  3. Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
  4. Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
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This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.

Technical details

dbSNP ID
rs174553
Position
chr11:61807686

Genome-wide association studies (20)

TraitRisk alleleOR / betaP-valueStudy
Degree of unsaturation G OR 0.37 2E-3356 PubMed
Degree of unsaturation G OR 0.34 2E-2409 PubMed
Ratio of monounsaturated fatty acids to total fatty acids A OR 0.15 2E-283 PubMed
Polyunsaturated fatty acid levels G — 3E-146 PubMed
Diacylglycerol (16:0_20:4) levels G OR 0.54 2E-129 PubMed
Cholesteryl Esters to Total Lipids in Large HDL percentage G β 0.05 1E-125 PubMed
Eicosanoid 8(S) HETrE levels — OR 0.4 1E-118 PubMed
Polyunsaturated fatty acid levels G — 3E-116 PubMed
1-linoleoyl-GPE (18:2) levels G OR 0.37 1E-92 PubMed
Lysophosphatidylcholine (20:5) [sn2] levels G OR 0.41 1E-73 PubMed
Average diameter for VLDL particles A β 0.073 7E-72 PubMed
Lysophosphatidylcholine (20:5) [sn2] levels G OR 0.41 3E-71 PubMed
Lysophosphatidylcholine (20:5) [sn1] levels G OR 0.4 9E-71 PubMed
1-stearoyl-2-linoleoyl-GPE (18:0/18:2) levels G OR 0.28 2E-70 PubMed
Cholesteryl ester levels in chylomicrons and extremely large VLDL A β 0.073 7E-69 PubMed
Lysophosphatidylcholine (20:5) [sn1] levels G OR 0.4 1E-68 PubMed
Cholesterol levels in chylomicrons and extremely large VLDL A β 0.072 7E-66 PubMed
Free cholesterol levels in chylomicrons and extremely large VLDL A β 0.068 1E-59 PubMed
Total lipid levels in chylomicrons and extremely large VLDL A β 0.066 4E-57 PubMed
Concentration of chylomicrons and extremely large VLDL particles A β 0.066 1E-56 PubMed

Sources