Genetic variant

rs174548

rs174548 is a single-letter difference in human DNA, on chromosome 11. Carrying it does not, on its own, mean you have or will develop any condition.

Register free Do I have this variant?

What is this?

Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs174548 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.

FADS1 codes for an enzyme involved in fatty acid unsaturation and the FADS1 gene SNP rs174548 seems ...

From SNPedia

Why might it matter?

ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.

Do I have this variant?

If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs174548, if your test read this position.

Register free Upload DNA Log in

Connect this with your blood results

A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.

Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.

Upload blood results

What should I do next?

  1. Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
  2. Put it in context. Add your blood results, so the variant can be read against what your body is doing.
  3. Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
  4. Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
Register free Upload DNA Upload blood results Ask Dr. Hemsworth

This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.

Technical details

dbSNP ID
rs174548
Position
chr11:61803876

Genome-wide association studies (20)

TraitRisk alleleOR / betaP-valueStudy
Arachidonate 20:4n6-to-dihomo-linolenate 20:3n3 or n6 ratio C β 0.071 2E-361 PubMed
Lysophosphatidylethanolamine_22:4_[M-H]1- levels G OR 0.35 5E-267 PubMed
Lysophosphatidylcholine_20:4_[M+H]1+ levels G OR 0.4 4E-238 PubMed
Phosphatidylethanolamine_38:4_[M-H]1- levels G OR 0.22 2E-142 PubMed
1-pentadecanoyl-2-arachidonoyl-GPC (15:0/20:4) levels G OR 0.47 4E-141 PubMed
Cholesteryl ester_20:5_[M+NH4]1+ levels G OR 0.31 2E-140 PubMed
Phosphatidylcholine_37:4_[M+H]1+/Phosphatidylethanolamine_40:4_[M+H]1+/Phosphatidate_42:5_[M+NH4]1+ levels G OR 0.37 3E-119 PubMed
Phosphatidylcholine_36:3_[M+H]1+/Phosphatidylethanolamine_39:3_[M+H]1+/Phosphatidate_41:4_[M+NH4]1+ levels G OR 0.35 4E-115 PubMed
Phosphatidylcholine_38:5_[M+H]1+/Phosphatidylethanolamine_41:5_[M+H]1+/Phosphatidate_43:6_[M+NH4]1+ levels G OR 0.36 2E-114 PubMed
Fatty acid(20:4)_[M-H]1- levels G OR 0.18 8E-109 PubMed
Diacylglycerol_38:3_[M+H-H2O]1+ levels G OR 0.18 6E-100 PubMed
Arachidonate (20:4n6) levels G OR 0.37 1E-92 PubMed
Phosphatidylinositol_36:3_[M-H]1- levels G OR 0.23 9E-92 PubMed
Phosphatidylcholine_35:3_[M+H]1+/Phosphatidylethanolamine_38:3_[M+H]1+/Phosphatidate_40:4_[M+NH4]1+ levels G OR 0.22 3E-91 PubMed
Arachidonate (20:4n6) levels C β 0.049 1E-84 PubMed
Phosphatidylethanolamine_38:3_[M-H]1- levels G OR 0.15 4E-79 PubMed
Phosphatidylethanolamine_39:4_[M-H]1- levels G OR 0.19 2E-76 PubMed
1-palmitoleoyl-2-linolenoyl-GPC (16:1/18:3) levels G OR 0.35 6E-75 PubMed
Sterol ester (27:1/20:5) levels G OR 0.41 4E-74 PubMed
Phosphatidylcholine (18:0_20:5) levels G OR 0.41 5E-74 PubMed

Sources