Genetic variant
rs174546
rs174546 is a single-letter difference in human DNA, on chromosome 11. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs174546 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
Genome-wide association study of plasma polyunsaturated fatty acids in the InCHIANTI Study. Genetic ...
From SNPedia
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs174546, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs174546
- Position
- chr11:61802358
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Ratio of omega-3 fatty acids to total fatty acids | T | OR 0.31 | 7E-1217 | PubMed |
| Ratio of 22:6 docosahexaenoic acid to total fatty acids | T | OR 0.23 | 3E-674 | PubMed |
| Lysophosphatidylethanolamine_22:4_[M-H]1- levels | T | OR 0.35 | 5E-284 | PubMed |
| Lysophosphatidylcholine_20:4_[M+H]1+ levels | T | OR 0.41 | 3E-261 | PubMed |
| Triglycerides to total lipids ratio in very small VLDL | T | OR 0.13 | 1E-204 | PubMed |
| 1-palmitoyl-2-linoleoyl-GPE (16:0/18:2) levels | T | OR 0.3 | 1E-179 | PubMed |
| Triglycerides to total lipids ratio in small VLDL | T | OR 0.12 | 1E-178 | PubMed |
| Plasma omega-6 polyunsaturated fatty acid levels (gamma-linolenic acid) | T | OR 0.52 | 5E-171 | PubMed |
| Phosphatidylethanolamine_38:4_[M-H]1- levels | T | OR 0.22 | 2E-148 | PubMed |
| Cholesteryl ester_20:5_[M+NH4]1+ levels | T | OR 0.31 | 3E-147 | PubMed |
| Phosphatidylcholine acyl-alkyl C38:5 levels | C | OR 25.71 | 9E-146 | PubMed |
| 1-oleoyl-2-linoleoyl-GPE (18:1/18:2) levels | T | OR 0.4 | 7E-140 | PubMed |
| Phosphatidylcholine_37:4_[M+H]1+/Phosphatidylethanolamine_40:4_[M+H]1+/Phosphatidate_42:5_[M+NH4]1+ levels | T | OR 0.38 | 2E-130 | PubMed |
| Cholesteryl esters to total lipids ratio in chylomicrons and extremely large VLDL | T | OR 0.11 | 4E-127 | PubMed |
| Fatty acid(20:4)_[M-H]1- levels | T | OR 0.19 | 5E-121 | PubMed |
| Phosphatidylcholine_38:5_[M+H]1+/Phosphatidylethanolamine_41:5_[M+H]1+/Phosphatidate_43:6_[M+NH4]1+ levels | T | OR 0.36 | 1E-120 | PubMed |
| Mean diameter of VLDL particles | T | β 0.096 | 6E-119 | PubMed |
| Phosphatidylcholine_36:3_[M+H]1+/Phosphatidylethanolamine_39:3_[M+H]1+/Phosphatidate_41:4_[M+NH4]1+ levels | T | OR 0.34 | 2E-113 | PubMed |
| Ratio of polyunsaturated fatty acids to total fatty acids | T | β 0.091 | 3E-104 | PubMed |
| 1-palmitoyl-2-dihomo-linolenoyl-GPC (16:0/20:3n3 or 6) levels | T | OR 0.33 | 1E-100 | PubMed |
Sources
- dbSNP: rs174546 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies