Genetic variant
rs174541
rs174541 is a single-letter difference in human DNA, on chromosome 11. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs174541 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
We hold only the basic reference record for this variant: its ID and position. Many catalogued variants have never been linked to anything.
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs174541, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs174541
- Position
- chr11:61798436
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Fasting glucose | — | — | 1E-27 | PubMed |
| Phosphatidylcholine (18:0_22:6) levels | C | OR 0.23 | 1E-23 | PubMed |
| Daytime nap | C | β 0.009 | 2E-23 | PubMed |
| Red blood cell fatty acid levels | — | OR 0.18 | 3E-19 | PubMed |
| Concentration of large LDL particles | T | β 0.038 | 6E-19 | PubMed |
| Concentration of LDL particles (UKB data field 23429) | C | β 0.043 | 1E-18 | PubMed |
| Serum metabolite ratios in chronic kidney disease | C | OR 0.37 | 6E-17 | PubMed |
| Lysophosphatidylethanolamine (18:1) [sn1] levels | C | OR 0.19 | 9E-17 | PubMed |
| Concentration of large LDL particles (UKB data field 23530) | C | β 0.041 | 1E-16 | PubMed |
| Type 2 diabetes | T | — | 1E-15 | PubMed |
| Concentration of small LDL particles (UKB data field 23544) | C | β 0.036 | 3E-13 | PubMed |
| Trans fatty acid levels | T | β 0.003 | 4E-13 | PubMed |
| Total lipids in small LDL (UKB data field 23545) | C | β 0.035 | 7E-13 | PubMed |
| Cholesterol in small LDL (UKB data field 23547) | C | β 0.035 | 1E-12 | PubMed |
| Free cholesterol in medium VLDL (UKB data field 23507) | C | β 0.034 | 1E-11 | PubMed |
| Type 2 diabetes | C | β 0.028 | 2E-11 | PubMed |
| Free cholesterol in small VLDL (UKB data field 23514) | C | β 0.032 | 9E-11 | PubMed |
| Phosphatidylcholine acyl-alkyl C30:1 levels | C | OR 6.31 | 3E-10 | PubMed |
| Type 2 diabetes | C | β 0.029 | 9E-10 | PubMed |
| Metabolite levels | T | OR 0.28 | 3E-9 | PubMed |
Sources
- dbSNP: rs174541 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies