Genetic variant
rs174535
rs174535 is a single-letter difference in human DNA, on chromosome 11. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs174535 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
We hold only the basic reference record for this variant: its ID and position. Many catalogued variants have never been linked to anything.
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs174535, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs174535
- Position
- chr11:61783884
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Lysophosphatidylethanolamine_22:4_[M-H]1- levels | C | OR 0.35 | 2E-275 | PubMed |
| Lysophosphatidylcholine_20:4_[M+H]1+ levels | C | OR 0.4 | 1E-251 | PubMed |
| Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid) | T | β 0.07 | 1E-151 | PubMed |
| Phosphatidylethanolamine_38:4_[M-H]1- levels | C | OR 0.22 | 2E-147 | PubMed |
| Cholesteryl ester_20:5_[M+NH4]1+ levels | C | OR 0.3 | 9E-141 | PubMed |
| Free Cholesterol to Total Lipids in Very Large VLDL percentage | C | β 0.071 | 4E-128 | PubMed |
| Phosphatidylcholine_37:4_[M+H]1+/Phosphatidylethanolamine_40:4_[M+H]1+/Phosphatidate_42:5_[M+NH4]1+ levels | C | OR 0.37 | 2E-125 | PubMed |
| Phosphatidylcholine_38:5_[M+H]1+/Phosphatidylethanolamine_41:5_[M+H]1+/Phosphatidate_43:6_[M+NH4]1+ levels | C | OR 0.35 | 3E-115 | PubMed |
| Fatty acid(20:4)_[M-H]1- levels | C | OR 0.18 | 4E-114 | PubMed |
| Phosphatidylcholine_36:3_[M+H]1+/Phosphatidylethanolamine_39:3_[M+H]1+/Phosphatidate_41:4_[M+NH4]1+ levels | C | OR 0.33 | 1E-107 | PubMed |
| Phosphatidylcholine (O-16:1_20:4) levels | C | OR 0.4 | 1E-107 | PubMed |
| Diacylglycerol_38:3_[M+H-H2O]1+ levels | C | OR 0.17 | 8E-97 | PubMed |
| 1-arachidonoylglycerophosphocholine levels | T | β 0.056 | 2E-94 | PubMed |
| Phosphatidylinositol_36:3_[M-H]1- levels | C | OR 0.22 | 3E-91 | PubMed |
| Phosphatidylcholine_35:3_[M+H]1+/Phosphatidylethanolamine_38:3_[M+H]1+/Phosphatidate_40:4_[M+NH4]1+ levels | C | OR 0.21 | 2E-88 | PubMed |
| Phosphatidylethanolamine_39:4_[M-H]1- levels | C | OR 0.18 | 8E-78 | PubMed |
| Phosphatidylethanolamine_38:3_[M-H]1- levels | C | OR 0.15 | 2E-76 | PubMed |
| Phosphatidylcholine_35:4_[M+H]1+/Phosphatidylethanolamine_38:4_[M+H]1+/Phosphatidate_40:5_[M+NH4]1+ levels | C | OR 0.22 | 5E-76 | PubMed |
| Phosphatidylcholine_34:2_[M+H]1+/Phosphatidylethanolamine_37:2_[M+H]1+/Phosphatidate_39:3_[M+NH4]1+ levels | C | OR 0.21 | 4E-74 | PubMed |
| Phosphatidylcholine_31:2_[M+H]1+/Phosphatidylethanolamine_34:2_[M+H]1+/Phosphatidate_36:3_[M+NH4]1+ levels | C | OR 0.22 | 6E-71 | PubMed |
Sources
- dbSNP: rs174535 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies