Genetic variant
rs16998073
rs16998073 is a single-letter difference in human DNA, on chromosome 4. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs16998073 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
23andMe blog blood pressure High Blood Pressure (Hypertension) [GWAS:Diastolic Blood Pressure]
From SNPedia
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs16998073, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs16998073
- Position
- chr4:80263187
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Systolic blood pressure | A | β 0.05 | 3E-216 | PubMed |
| Diastolic blood pressure | A | β 0.049 | 9E-200 | PubMed |
| Diastolic blood pressure | — | OR 0.47 | 6E-115 | PubMed |
| Systolic blood pressure | — | OR 0.71 | 5E-111 | PubMed |
| Mean arterial pressure (BMI adjusted) | T | OR 1.31 | 3E-96 | PubMed |
| Diastolic blood pressure (BMI adjusted) | T | OR 1.09 | 2E-93 | PubMed |
| Mean arterial pressure (BMI unadjusted) | T | OR 1.28 | 9E-85 | PubMed |
| Diastolic blood pressure (BMI unadjusted) | T | OR 1.07 | 6E-84 | PubMed |
| Diastolic blood pressure | T | β 0.06 | 6E-63 | PubMed |
| creatinine (mean, inv-norm transformed) | A | β 0.045 | 1E-61 | PubMed |
| Systolic blood pressure | — | — | 2E-61 | PubMed |
| Diastolic blood pressure | T | β 0.035 | 9E-60 | PubMed |
| Diastolic blood pressure | A | OR 0.43 | 1E-59 | PubMed |
| creatinine (minimum, inv-norm transformed) | A | β 0.044 | 6E-58 | PubMed |
| Systolic blood pressure | A | OR 0.66 | 2E-53 | PubMed |
| Systolic blood pressure | T | β 0.054 | 1E-51 | PubMed |
| Hypertension (PheCode 401) | — | — | 2E-50 | PubMed |
| creatinine (maximum, inv-norm transformed) | A | β 0.039 | 6E-48 | PubMed |
| Essential hypertension (PheCode 401.1) | — | — | 2E-47 | PubMed |
| Mean arterial pressure | — | OR 0.81 | 4E-47 | PubMed |
Sources
- dbSNP: rs16998073 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies