Genetic variant
rs157581
rs157581 is a single-letter difference in human DNA, on chromosome 19. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs157581 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
Polygenic Analysis of Late-Onset Alzheimer's Disease from Mainland China.
From SNPedia
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs157581, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs157581
- Position
- chr19:44892457
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Alzheimer's disease or family history of Alzheimer's disease | C | — | 9E-188 | PubMed |
| Aging | T | β 0.016 | 1E-27 | PubMed |
| MOB-like protein phocein level in Chronic kidney disease with hypertension and no diabetes (19332_1) | C | OR 0.57 | 3E-22 | PubMed |
| Memory decline | — | β 0.012 | 7E-22 | PubMed |
| Baseline memory | — | OR 0.1 | 4E-19 | PubMed |
| Memory decline | — | β 0.012 | 5E-16 | PubMed |
| Memory decline | — | β 0.013 | 1E-15 | PubMed |
| Baseline memory | — | OR 0.19 | 2E-14 | PubMed |
| Baseline memory in impaired cognition | — | OR 0.23 | 6E-12 | PubMed |
| Cerebral amyloid deposition (PET imaging) | C | β 0.1 | 9E-12 | PubMed |
| Memory decline | — | β 0.01 | 1E-11 | PubMed |
| Memory decline in impaired cognition | — | β 0.036 | 7E-11 | PubMed |
| Memory decline in normal cognition | — | β 0.009 | 6E-10 | PubMed |
| Baseline memory | — | β 0.078 | 8E-10 | PubMed |
| Memory decline in normal cognition | — | β 0.009 | 4E-9 | PubMed |
| Linoleic acid to total fatty acids percentage | C | — | 1E-8 | PubMed |
| Memory decline in normal cognition | — | β 0.009 | 3E-8 | PubMed |
| Memory decline in normal cognition | — | β 0.007 | 3E-8 | PubMed |
| Baseline memory | — | β 0.079 | 4E-8 | PubMed |
| Memory decline | — | β 0.015 | 1E-7 | PubMed |
Sources
- dbSNP: rs157581 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies