Genetic variant
rs157580
rs157580 is a single-letter difference in human DNA, on chromosome 19. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs157580 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
The G allele of this SNP in the TOMM40 gene may be associated with late-onset Alzheimer's disease. A...
From SNPedia
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs157580, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs157580
- Position
- chr19:44892009
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Alzheimer's disease or family history of Alzheimer's disease | G | OR 31.65 | 8E-220 | PubMed |
| Alzheimer's disease or family history of Alzheimer's disease | — | — | 2E-208 | PubMed |
| Alzheimer's disease (MTAG) | G | β 0.065 | 9E-186 | PubMed |
| Alzheimer's disease | A | OR 0.4 | 1E-160 | PubMed |
| Alzheimer's disease (MTAG) | G | β 0.05 | 6E-138 | PubMed |
| Alzheimer's disease (MTAG) | G | β 0.045 | 1E-133 | PubMed |
| Alzheimer's disease (MTAG) | G | β 0.048 | 4E-130 | PubMed |
| Family history of Alzheimer's disease | — | — | 6E-120 | PubMed |
| Alzheimer's disease (MTAG) | G | β 0.031 | 6E-92 | PubMed |
| Alzheimer's disease | — | OR 1.69 | 8E-89 | PubMed |
| Alzheimer's disease or family history of Alzheimer's disease | A | — | 2E-60 | PubMed |
| Alzheimer's disease | — | — | 1E-40 | PubMed |
| IGSF8/NECTIN2 protein level ratio | — | β 0.078 | 2E-29 | PubMed |
| LDL cholesterol | G | OR 0.11 | 2E-19 | PubMed |
| CPM/PCSK9 protein level ratio | — | β 0.06 | 5E-19 | PubMed |
| Cholesteryl esters in chylomicrons and extremely large VLDL (UKB data field 23485) | G | β 0.038 | 9E-16 | PubMed |
| Alzheimer's disease | — | OR 1.69 | 6E-14 | PubMed |
| Triglycerides in very small VLDL (UKB data field 23522) | G | β 0.034 | 4E-13 | PubMed |
| Triglycerides to phosphoglycerides ratio (UKB data field 23435) | G | β 0.03 | 2E-11 | PubMed |
| 1-stearoyl-gpc (18:0) levels | A | β 0.064 | 5E-10 | PubMed |
Sources
- dbSNP: rs157580 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies